Title |
Recent Advances in Understanding the Pathogenesis of Scleroderma-Interstitial Lung Disease
|
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Published in |
Current Rheumatology Reports, February 2014
|
DOI | 10.1007/s11926-014-0411-1 |
Pubmed ID | |
Authors |
Tanjina Akter, Richard M. Silver, Galina S. Bogatkevich |
Abstract |
Systemic sclerosis (scleroderma, SSc) is a heterogeneous autoimmune connective tissue disease of unknown etiology. Interstitial lung disease (ILD) is a frequent complication, and a significant contributor to morbidity and mortality among SSc patients. SSc-ILD most commonly occurs within 10 years of diagnosis, and may be seen in patients with either the limited or diffuse cutaneous subset of SSc. SSc-ILD is a multifaceted disease process in which different factors and pathways are involved. Aberrant function of a variety of lung cells, cytokines, growth factors, peptides, and bioactive proteins, in combination with genetic and epigenetic regulators, have crucial functions in the pathogenesis of this disease. Here we present our view on recent advances regarding the pathogenesis of SSc-ILD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 75 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 13 | 17% |
Researcher | 11 | 15% |
Other | 9 | 12% |
Student > Postgraduate | 9 | 12% |
Student > Ph. D. Student | 3 | 4% |
Other | 8 | 11% |
Unknown | 22 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 31 | 41% |
Agricultural and Biological Sciences | 7 | 9% |
Biochemistry, Genetics and Molecular Biology | 6 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Nursing and Health Professions | 1 | 1% |
Other | 2 | 3% |
Unknown | 26 | 35% |