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Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients

Overview of attention for article published in PLOS ONE, February 2014
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Title
Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients
Published in
PLOS ONE, February 2014
DOI 10.1371/journal.pone.0090505
Pubmed ID
Authors

Kate L. Fox, John M. Atack, Yogitha N. Srikhanta, Anja Eckert, Laura A. Novotny, Lauren O. Bakaletz, Michael P. Jennings

Abstract

Surface structures in Haemophilus influenzae are subject to rapid ON/OFF switching of expression, a process termed phase variation. We analyse tetranucleotide repeats controlling phase variation in lipo-oligosaccharide (LOS) genes of H. influenzae in paired isolates from both the nasopharynx and middle ears of paediatric patients with chronic or recurrent otitis media. A change in expression of at least one of the seven phase variable LOS biosynthesis genes was seen in 12 of the 21 strain pairs. Several strains showed switching of expression in multiple LOS genes, consistent with a key role for phase variable LOS biosynthetic genes in human infection.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 32%
Student > Bachelor 4 13%
Student > Doctoral Student 3 10%
Student > Postgraduate 3 10%
Other 2 6%
Other 6 19%
Unknown 3 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 29%
Biochemistry, Genetics and Molecular Biology 5 16%
Medicine and Dentistry 5 16%
Immunology and Microbiology 2 6%
Business, Management and Accounting 1 3%
Other 3 10%
Unknown 6 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2014.
All research outputs
#15,295,786
of 22,747,498 outputs
Outputs from PLOS ONE
#130,412
of 194,162 outputs
Outputs of similar age
#131,161
of 221,024 outputs
Outputs of similar age from PLOS ONE
#3,774
of 5,923 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 194,162 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,024 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5,923 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.