Title |
Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients
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Published in |
PLOS ONE, February 2014
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DOI | 10.1371/journal.pone.0090505 |
Pubmed ID | |
Authors |
Kate L. Fox, John M. Atack, Yogitha N. Srikhanta, Anja Eckert, Laura A. Novotny, Lauren O. Bakaletz, Michael P. Jennings |
Abstract |
Surface structures in Haemophilus influenzae are subject to rapid ON/OFF switching of expression, a process termed phase variation. We analyse tetranucleotide repeats controlling phase variation in lipo-oligosaccharide (LOS) genes of H. influenzae in paired isolates from both the nasopharynx and middle ears of paediatric patients with chronic or recurrent otitis media. A change in expression of at least one of the seven phase variable LOS biosynthesis genes was seen in 12 of the 21 strain pairs. Several strains showed switching of expression in multiple LOS genes, consistent with a key role for phase variable LOS biosynthetic genes in human infection. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 32% |
Student > Bachelor | 4 | 13% |
Student > Doctoral Student | 3 | 10% |
Student > Postgraduate | 3 | 10% |
Other | 2 | 6% |
Other | 6 | 19% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 9 | 29% |
Biochemistry, Genetics and Molecular Biology | 5 | 16% |
Medicine and Dentistry | 5 | 16% |
Immunology and Microbiology | 2 | 6% |
Business, Management and Accounting | 1 | 3% |
Other | 3 | 10% |
Unknown | 6 | 19% |