Title |
Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.
|
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Published in |
Stroke, November 1984
|
DOI | 10.1161/01.str.15.6.1012 |
Pubmed ID | |
Authors |
L E Brattstrom, J E Hardebo, B L Hultberg |
Abstract |
Highly elevated concentrations of homocysteine measured as homocysteine or cysteine-homocysteine mixed disulfide (MDS) are found in plasma and urine in subjects with inherited abnormalities of the methionine metabolism. These subjects have a high incidence of arteriosclerotic vascular complications during childhood. Homocysteine causes endothelial cell injury and cell detachment that initiates the development of arteriosclerosis. The present study demonstrates a significantly elevated mean plasma MDS concentration in 19 patients with arteriosclerotic cerebrovascular disease compared to 17 controls. Our findings suggest that moderate homocysteinemia might be a risk factor for arteriosclerotic cerebrovascular disease. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 19% |
Student > Bachelor | 3 | 19% |
Researcher | 2 | 13% |
Other | 1 | 6% |
Student > Ph. D. Student | 1 | 6% |
Other | 3 | 19% |
Unknown | 3 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 44% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 13% |
Agricultural and Biological Sciences | 1 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Psychology | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 19% |