Title |
Neurofibromatosis type I with breast cancer: not only for women!
|
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Published in |
Hereditary Cancer in Clinical Practice, February 2014
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DOI | 10.1186/1897-4287-12-5 |
Pubmed ID | |
Authors |
Kuntegowdanahalli Chinnagiriyappa Lakshmaiah, Anil N Kumar, Samit Purohit, Belathur Kalegowda Viveka, Kamalakannan Rahul Rajan, Mohammed Abdul Lateef Zameer, Prabhu Namitha, Monika Lamba Saini, Hatem A Azim, Kamal S Saini |
Abstract |
The association of neurofibromatosis type I with invasive male breast cancer is a rare clinical entity with only one case in literature reported in 1953. Women with NF1 are at risk of developing breast cancer and men also may be at risk but there is scarce data on the risk and association of NF1 with male breast cancer due to its rarity. Established clinical trials in male breast cancer patients are lacking and the results are extrapolated from female breast cancer patients. The treatment of male breast cancer is followed as per the guidelines of premenopausal female breast cancer and tamoxifen is the hormone treatment in them. Mendes et al suggests that silencing of NF1 gene confers resistance to tamoxifen. Our conclusions are that since NF1 is mutated or deleted in one third of sporadic breast cancers, its role as a molecular driver for treatment has to be further explored. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 2 | 13% |
Student > Postgraduate | 2 | 13% |
Researcher | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Unspecified | 1 | 6% |
Other | 2 | 13% |
Unknown | 5 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 50% |
Unspecified | 1 | 6% |
Agricultural and Biological Sciences | 1 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Unknown | 5 | 31% |