| Title |
Major histocompatibility complex variation and the evolution of resistance to amphibian chytridiomycosis
|
|---|---|
| Published in |
Immunogenetics, July 2017
|
| DOI | 10.1007/s00251-017-1008-4 |
| Pubmed ID | |
| Authors |
Minjie Fu, Bruce Waldman |
| Abstract |
Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Analyses of transcriptional expression in hosts following their infection by Bd reveal complex responses. Species resistant to Bd generally show evidence of stronger innate and adaptive immune system responses. Major histocompatibility complex (MHC) class I and class II genes of some susceptible species are up-regulated following host infection by Bd, but resistant species show no comparable changes in transcriptional expression. Bd-resistant species share similar pocket conformations within the MHC-II antigen-binding groove. Among susceptible species, survivors of epizootics bear alleles encoding these conformations. Individuals with homozygous resistance alleles appear to benefit by enhanced resistance, especially in environmental conditions that promote pathogen virulence. Subjects that are repeatedly infected and subsequently cleared of Bd can develop an acquired immune response to the pathogen. Strong directional selection for MHC alleles that encode resistance to Bd may deplete genetic variation necessary to respond to other pathogens. Resistance to chytridiomycosis incurs life-history costs that require further study. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 5 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 40% |
| Scientists | 2 | 40% |
| Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 103 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 23% |
| Researcher | 18 | 17% |
| Student > Master | 14 | 14% |
| Student > Bachelor | 13 | 13% |
| Student > Doctoral Student | 5 | 5% |
| Other | 13 | 13% |
| Unknown | 16 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 45 | 44% |
| Biochemistry, Genetics and Molecular Biology | 17 | 17% |
| Environmental Science | 8 | 8% |
| Veterinary Science and Veterinary Medicine | 5 | 5% |
| Immunology and Microbiology | 4 | 4% |
| Other | 5 | 5% |
| Unknown | 19 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2017.
All research outputs
#13,486,152
of 22,988,380 outputs
Outputs from Immunogenetics
#886
of 1,202 outputs
Outputs of similar age
#157,520
of 312,577 outputs
Outputs of similar age from Immunogenetics
#14
of 27 outputs
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