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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Mutations in TJP2 cause progressive cholestatic liver disease
|
|---|---|
| Published in |
Nature Genetics, March 2014
|
| DOI | 10.1038/ng.2918 |
| Pubmed ID | |
| Authors |
Melissa Sambrotta, Sandra Strautnieks, Efterpi Papouli, Peter Rushton, Barnaby E Clark, David A Parry, Clare V Logan, Lucy J Newbury, Binita M Kamath, Simon Ling, Tassos Grammatikopoulos, Bart E Wagner, John C Magee, Ronald J Sokol, Giorgina Mieli-Vergani, Joshua D Smith, Colin A Johnson, Patricia McClean, Michael A Simpson, A S Knisely, Laura N Bull, Richard J Thompson |
| Abstract |
Elucidating genetic causes of cholestasis has proved to be important in understanding the physiology and pathophysiology of the liver. Here we show that protein-truncating mutations in the tight junction protein 2 gene (TJP2) cause failure of protein localization and disruption of tight-junction structure, leading to severe cholestatic liver disease. These findings contrast with those in the embryonic-lethal knockout mouse, highlighting differences in redundancy in junctional complexes between organs and species. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 40% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 80% |
| Members of the public | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| France | 1 | <1% |
| Unknown | 136 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 21% |
| Student > Ph. D. Student | 21 | 15% |
| Student > Master | 12 | 9% |
| Other | 10 | 7% |
| Student > Bachelor | 8 | 6% |
| Other | 27 | 19% |
| Unknown | 32 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 31 | 22% |
| Agricultural and Biological Sciences | 26 | 19% |
| Biochemistry, Genetics and Molecular Biology | 25 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Immunology and Microbiology | 2 | 1% |
| Other | 9 | 6% |
| Unknown | 38 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2019.
All research outputs
#1,159,266
of 22,747,498 outputs
Outputs from Nature Genetics
#1,862
of 7,185 outputs
Outputs of similar age
#12,514
of 221,061 outputs
Outputs of similar age from Nature Genetics
#36
of 74 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,185 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.0. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 221,061 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.