Title |
Cannabinoids and Gliomas
|
---|---|
Published in |
Molecular Neurobiology, June 2007
|
DOI | 10.1007/s12035-007-0002-5 |
Pubmed ID | |
Authors |
Guillermo Velasco, Arkaitz Carracedo, Cristina Blázquez, Mar Lorente, Tania Aguado, Amador Haro, Cristina Sánchez, Ismael Galve-Roperh, Manuel Guzmán |
Abstract |
Cannabinoids, the active components of Cannabis sativa L., act in the body by mimicking endogenous substances--the endocannabinoids--that activate specific cell surface receptors. Cannabinoids exert various palliative effects in cancer patients. In addition, cannabinoids inhibit the growth of different types of tumor cells, including glioma cells, in laboratory animals. They do so by modulating key cell signaling pathways, mostly the endoplasmic reticulum stress response, thereby inducing antitumoral actions such as the apoptotic death of tumor cells and the inhibition of tumor angiogenesis. Of interest, cannabinoids seem to be selective antitumoral compounds, as they kill glioma cells, but not their non-transformed astroglial counterparts. On the basis of these preclinical findings, a pilot clinical study of Delta(9)-tetrahydrocannabinol (THC) in patients with recurrent glioblastoma multiforme has been recently run. The good safety profile of THC, together with its possible growth-inhibiting action on tumor cells, justifies the setting up of future trials aimed at evaluating the potential antitumoral activity of cannabinoids. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 14 | 4% |
United Kingdom | 12 | 4% |
Australia | 4 | 1% |
Ireland | 2 | <1% |
Argentina | 2 | <1% |
Norway | 2 | <1% |
Georgia | 2 | <1% |
Turkey | 2 | <1% |
Other | 21 | 7% |
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Demographic breakdown
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---|---|---|
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Scientists | 3 | <1% |
Science communicators (journalists, bloggers, editors) | 2 | <1% |
Practitioners (doctors, other healthcare professionals) | 1 | <1% |
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Mendeley readers
Geographical breakdown
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---|---|---|
United States | 2 | 1% |
Spain | 2 | 1% |
India | 1 | <1% |
Netherlands | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 136 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 34 | 24% |
Student > Bachelor | 20 | 14% |
Student > Master | 17 | 12% |
Student > Ph. D. Student | 14 | 10% |
Professor | 12 | 8% |
Other | 24 | 17% |
Unknown | 22 | 15% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 25 | 17% |
Biochemistry, Genetics and Molecular Biology | 17 | 12% |
Neuroscience | 12 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Other | 28 | 20% |
Unknown | 28 | 20% |