| Title |
Small molecules for reprogramming and transdifferentiation
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, July 2017
|
| DOI | 10.1007/s00018-017-2586-x |
| Pubmed ID | |
| Authors |
Hua Qin, Andong Zhao, Xiaobing Fu |
| Abstract |
Pluripotency reprogramming and transdifferentiation induced by transcription factors can generate induced pluripotent stem cells, adult stem cells or specialized cells. However, the induction efficiency and the reintroduction of exogenous genes limit their translation into clinical applications. Small molecules that target signaling pathways, epigenetic modifications, or metabolic processes can regulate cell development, cell fate, and function. In the recent decade, small molecules have been widely used in reprogramming and transdifferentiation fields, which can promote the induction efficiency, replace exogenous genes, or even induce cell fate conversion alone. Small molecules are expected as novel approaches to generate new cells from somatic cells in vitro and in vivo. Here, we will discuss the recent progress, new insights, and future challenges about the use of small molecules in cell fate conversion. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 11% |
| Korea, Republic of | 1 | 11% |
| France | 1 | 11% |
| Unknown | 6 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 56% |
| Science communicators (journalists, bloggers, editors) | 2 | 22% |
| Scientists | 2 | 22% |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 145 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 16% |
| Student > Bachelor | 21 | 14% |
| Student > Master | 19 | 13% |
| Researcher | 17 | 12% |
| Student > Postgraduate | 6 | 4% |
| Other | 22 | 15% |
| Unknown | 37 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 48 | 33% |
| Agricultural and Biological Sciences | 18 | 12% |
| Medicine and Dentistry | 16 | 11% |
| Neuroscience | 12 | 8% |
| Immunology and Microbiology | 2 | 1% |
| Other | 10 | 7% |
| Unknown | 39 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 October 2022.
All research outputs
#1,406,161
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#125
of 4,151 outputs
Outputs of similar age
#28,818
of 313,730 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#3
of 63 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 313,730 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.