| Title |
129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal
|
|---|---|
| Published in |
Molecular Neurobiology, April 1994
|
| DOI | 10.1007/bf02780662 |
| Pubmed ID | |
| Authors |
J. C. Manson, A. R. Clarke, M. L. Hooper, L. Aitchison, I. McConnell, J. Hope |
| Abstract |
The neural membrane glycoprotein PrP is implicated in the pathogenesis of the transmissible spongiform encephalopathies; however, the normal function of PrP and its precise role in disease are not understood. Recently, gene targeting has been used to produce mice with neo/PrP fusion transcripts, but no detectable PrP protein in the brain (1). Here we report the use of a different targeting strategy, to produce inbred mice with a complete absence of both PrP protein and mRNA sequences. At 7 mo of age, these mice show no overt phenotypic abnormalities despite the normal high levels of expression of PrP during mouse development. The mice are being used in experiments designed to address the role of PrP in the pathogenesis of scrapie and the replication of infectivity. |
Mendeley readers
The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 100 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 23 | 23% |
| Student > Ph. D. Student | 22 | 22% |
| Student > Bachelor | 10 | 10% |
| Student > Master | 8 | 8% |
| Student > Postgraduate | 6 | 6% |
| Other | 14 | 14% |
| Unknown | 19 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 30 | 29% |
| Biochemistry, Genetics and Molecular Biology | 18 | 18% |
| Neuroscience | 14 | 14% |
| Medicine and Dentistry | 6 | 6% |
| Veterinary Science and Veterinary Medicine | 2 | 2% |
| Other | 10 | 10% |
| Unknown | 22 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 October 2020.
All research outputs
#3,775,334
of 22,747,498 outputs
Outputs from Molecular Neurobiology
#813
of 3,434 outputs
Outputs of similar age
#2,272
of 22,976 outputs
Outputs of similar age from Molecular Neurobiology
#1
of 2 outputs
Altmetric has tracked 22,747,498 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,434 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 76% of its peers.
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