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Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury

Overview of attention for article published in American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, April 2010
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Average Attention Score compared to outputs of the same age and source

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5 X users
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1 Facebook page

Citations

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150 Dimensions

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198 Mendeley
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1 CiteULike
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Title
Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury
Published in
American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, April 2010
DOI 10.1152/ajpregu.00467.2009
Pubmed ID
Authors

Jonathan Peake, Paul Della Gatta, David Cameron-Smith

Abstract

The world's elderly population is expanding rapidly, and we are now faced with the significant challenge of maintaining or improving physical activity, independence, and quality of life in the elderly. Counteracting the progressive loss of muscle mass that occurs in the elderly, known as sarcopenia, represents a major hurdle in achieving these goals. Indirect evidence for a role of inflammation in sarcopenia is that markers of systemic inflammation correlate with the loss of muscle mass and strength in the elderly. More direct evidence is that compared with skeletal muscle of young people, the number of macrophages is lower, the gene expression of several cytokines is higher, and stress signaling proteins are activated in skeletal muscle of elderly people at rest. Sarcopenia may also result from inadequate repair and chronic maladaptation following muscle injury in the elderly. Macrophage infiltration and the gene expression of certain cytokines are reduced in skeletal muscle of elderly people compared with young people following exercise-induced muscle injury. Further research is required to identify the cause(s) of inflammation in skeletal muscle of elderly people. Additional work is also needed to expand our understanding of the cells, proteins, and transcription factors that regulate inflammation in the skeletal muscle of elderly people at rest and after exercise. This knowledge is critical for devising strategies to restrict sarcopenia, and improve the health of today's elderly population.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 1%
Norway 1 <1%
Sweden 1 <1%
Malaysia 1 <1%
Czechia 1 <1%
Denmark 1 <1%
Greece 1 <1%
United States 1 <1%
Unknown 189 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 40 20%
Student > Master 29 15%
Researcher 20 10%
Student > Bachelor 20 10%
Student > Doctoral Student 12 6%
Other 40 20%
Unknown 37 19%
Readers by discipline Count As %
Medicine and Dentistry 44 22%
Sports and Recreations 30 15%
Agricultural and Biological Sciences 26 13%
Biochemistry, Genetics and Molecular Biology 25 13%
Nursing and Health Professions 6 3%
Other 23 12%
Unknown 44 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2014.
All research outputs
#8,510,305
of 25,457,858 outputs
Outputs from American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
#846
of 2,485 outputs
Outputs of similar age
#37,884
of 102,893 outputs
Outputs of similar age from American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
#16
of 31 outputs
Altmetric has tracked 25,457,858 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 2,485 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,893 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.