| Title |
Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: a systematic review and meta-analysis
|
|---|---|
| Published in |
Endocrine, August 2016
|
| DOI | 10.1007/s12020-016-1014-6 |
| Pubmed ID | |
| Authors |
Yanjue Shen, Rongrong Cai, Jie Sun, Xue Dong, Rong Huang, Sai Tian, Shaohua Wang |
| Abstract |
Diabetes mellitus is a strong risk factor for chronic kidney disease and end-stage renal disease. Whether sex differences in chronic kidney disease and end-stage renal disease incidence exist among diabetic patients remains unclear. This systematic review and meta-analysis was conducted to evaluate the relative effect of diabetes on chronic kidney disease and end-stage renal disease risk in women compared with men. We systematically searched Embase, PubMed, and the Cochrane Library for both cohort and case-control studies until October 2015. Studies were selected if they reported a sex-specific relationship between diabetes mellitus and chronic kidney disease or end-stage renal disease. We generated pooled estimates across studies using random-effects meta-analysis after log transformation with inverse variance weighting. Ten studies with data from more than 5 million participants were included. The pooled adjusted risk ratio of chronic kidney disease associated with diabetes mellitus was 3.34 (95 % CI 2.27, 4.93) in women and 2.84 (95 % CI 1.73, 4.68) in men. The data showed no difference in diabetes-related chronic kidney disease risk between the sexes (pooled adjusted women-to-men relative risk ratio was 1.14 [95 % CI 0.97, 1.34]) except for end-stage renal disease-the pooled adjusted women-to men relative risk ratio was 1.38 (95 % CI 1.22, 1.55; p = 0.114, I² = 38.1 %). The study found no evidence of a sex difference in the association between diabetes mellitus and chronic kidney disease. However, the excess risk for end-stage renal disease was higher in women with diabetes than in men with the same condition, from which we assume that the female gender could accelerate the disease progression. Further studies are needed to support this notion and elucidate the underlying mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 183 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 183 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 25 | 14% |
| Student > Master | 23 | 13% |
| Student > Ph. D. Student | 17 | 9% |
| Researcher | 11 | 6% |
| Student > Postgraduate | 11 | 6% |
| Other | 37 | 20% |
| Unknown | 59 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 60 | 33% |
| Nursing and Health Professions | 22 | 12% |
| Biochemistry, Genetics and Molecular Biology | 12 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 19 | 10% |
| Unknown | 62 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 November 2023.
All research outputs
#2,374,204
of 24,842,061 outputs
Outputs from Endocrine
#119
of 1,858 outputs
Outputs of similar age
#43,161
of 375,189 outputs
Outputs of similar age from Endocrine
#4
of 41 outputs
Altmetric has tracked 24,842,061 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,858 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done particularly well, scoring higher than 93% of its peers.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.