| Title |
Retinopathy with central oedema in an INSC94Y transgenic pig model of long-term diabetes
|
|---|---|
| Published in |
Diabetologia, May 2017
|
| DOI | 10.1007/s00125-017-4290-7 |
| Pubmed ID | |
| Authors |
Kristina J. H. Kleinwort, Barbara Amann, Stefanie M. Hauck, Sieglinde Hirmer, Andreas Blutke, Simone Renner, Patrizia B. Uhl, Karina Lutterberg, Walter Sekundo, Eckhard Wolf, Cornelia A. Deeg |
| Abstract |
Diabetic retinopathy is a severe complication of diabetes mellitus that often leads to blindness. Because the pathophysiology of diabetic retinopathy is not fully understood and novel therapeutic interventions require testing, there is a need for reliable animal models that mimic all the complications of diabetic retinopathy. Pig eyes share important anatomical and physiological similarities with human eyes. Previous studies have demonstrated that INS (C94Y) transgenic pigs develop a stable diabetic phenotype and ocular alterations such as cataracts. The aim of this study was to conduct an in-depth analysis of pathological changes in retinas from INS (C94Y) pigs exposed to hyperglycaemia for more than 2 years, representing a chronic diabetic condition. Eyes from six INS (C94Y)pigs and six age-matched control littermates were analysed via histology and immunohistochemistry. For histological analyses of retinal (layer) thickness, sections were stained with H&E or Mallory's trichrome. For comparison of protein expression patterns and vessel courses, sections were stained with different antibodies in immunohistochemistry. Observed lesions were compared with reported pathologies in human diabetic retinopathy. INS (C94Y)pigs developed several signs of diabetic retinopathy similar to those seen in humans, such as intraretinal microvascular abnormalities, symptoms of proliferative diabetic retinopathy and central retinal oedema in a region that is cone rich, like the human macula. The INS (C94Y)pig is an interesting model for studying the pathophysiology of diabetic retinopathy and for testing novel therapeutic strategies. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 33 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 15% |
| Student > Ph. D. Student | 5 | 15% |
| Student > Doctoral Student | 3 | 9% |
| Researcher | 3 | 9% |
| Student > Master | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 13 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 18% |
| Agricultural and Biological Sciences | 3 | 9% |
| Nursing and Health Professions | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Other | 1 | 3% |
| Unknown | 15 | 45% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 August 2017.
All research outputs
#17,905,157
of 22,988,380 outputs
Outputs from Diabetologia
#4,667
of 5,085 outputs
Outputs of similar age
#221,994
of 310,575 outputs
Outputs of similar age from Diabetologia
#72
of 72 outputs
Altmetric has tracked 22,988,380 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,085 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 310,575 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.