| Title |
Do mitochondria have an immune system?
|
|---|---|
| Published in |
Biochemistry, October 2016
|
| DOI | 10.1134/s0006297916100217 |
| Pubmed ID | |
| Authors |
V. A. Popkov, L. D. Zorova, I. O. Korvigo, D. N. Silachev, S. S. Jankauskas, V. A. Babenko, I. B. Pevzner, T. I. Danilina, S. D. Zorov, E. Y. Plotnikov, D. B. Zorov |
| Abstract |
The question if mitochondria have some kind of immune system is not trivial. The basis for raising this question is the fact that bacteria, which are progenitors of mitochondria, do have an immune system. The CRISPR system in bacteria based on the principle of RNA interference serves as an organized mechanism for destroying alien nucleic acids, primarily those of viral origin. We have shown that mitochondria are also a target for viral attacks, probably due to a related organization of genomes in these organelles and bacteria. Bioinformatic analysis performed in this study has not given a clear answer if there is a CRISPR-like immune system in mitochondria. However, this does not preclude the possibility of mitochondrial immunity that can be difficult to decipher or that is based on some principles other than those of CRISPR. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 13% |
| Unknown | 7 | 88% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 25% |
| Student > Ph. D. Student | 4 | 20% |
| Student > Master | 3 | 15% |
| Student > Bachelor | 2 | 10% |
| Student > Postgraduate | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 5 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 35% |
| Biochemistry, Genetics and Molecular Biology | 5 | 25% |
| Computer Science | 1 | 5% |
| Chemical Engineering | 1 | 5% |
| Unknown | 6 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2018.
All research outputs
#6,800,463
of 25,630,321 outputs
Outputs from Biochemistry
#6,554
of 22,363 outputs
Outputs of similar age
#94,846
of 323,842 outputs
Outputs of similar age from Biochemistry
#21
of 129 outputs
Altmetric has tracked 25,630,321 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 22,363 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,842 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.