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Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression

Overview of attention for article published in Behavioural Brain Research, July 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

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1 news outlet
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4 X users

Citations

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18 Dimensions

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63 Mendeley
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Title
Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression
Published in
Behavioural Brain Research, July 2017
DOI 10.1016/j.bbr.2017.07.006
Pubmed ID
Authors

Alexander Levit, Aaron M. Regis, Jessica R. Garabon, Seung-Hun Oh, Sagar J. Desai, Nagalingam Rajakumar, Vladimir Hachinski, Yuksel Agca, Cansu Agca, Shawn N. Whitehead, Brian L. Allman

Abstract

Alzheimer disease (AD) and stroke coexist and interact; yet how they interact is not sufficiently understood. Both AD and basal ganglia stroke can impair behavioural flexibility, which can be reliably modeled in rats using an established operant based set-shifting test. Transgenic Fischer 344-APP21 rats (TgF344) overexpress pathogenic human amyloid precursor protein (hAPP) but do not spontaneously develop overt pathology, hence TgF344 rats can be used to model the effect of vascular injury in the prodromal stages of Alzheimer disease. We demonstrate that the injection of endothelin-1 (ET1) into the dorsal striatum of TgF344 rats (Tg-ET1) produced an exacerbation of behavioural inflexibility with a behavioural phenotype that was distinct from saline-injected wildtype & TgF344 rats as well as ET1-injected wildtype rats (Wt-ET1). In addition to profiling the types of errors made, interpolative modeling using logistic exposure-response regression provided an informative analysis of the timing and efficiency of behavioural flexibility. During set-shifting, Tg-ET1 committed fewer perseverative errors than Wt-ET1. However, Tg-ET1 committed significantly more regressive errors and had a less efficient strategy change than all other groups. Thus, behavioural flexibility was more vulnerable to striatal ischemic injury in TgF344.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 16%
Student > Ph. D. Student 9 14%
Researcher 7 11%
Student > Bachelor 6 10%
Other 3 5%
Other 11 17%
Unknown 17 27%
Readers by discipline Count As %
Neuroscience 10 16%
Psychology 8 13%
Medicine and Dentistry 6 10%
Biochemistry, Genetics and Molecular Biology 5 8%
Agricultural and Biological Sciences 4 6%
Other 9 14%
Unknown 21 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2017.
All research outputs
#2,967,241
of 25,382,440 outputs
Outputs from Behavioural Brain Research
#469
of 4,975 outputs
Outputs of similar age
#51,963
of 324,847 outputs
Outputs of similar age from Behavioural Brain Research
#7
of 95 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,975 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,847 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.