Title |
From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling
|
---|---|
Published in |
Cancer Cell, March 2014
|
DOI | 10.1016/j.ccr.2014.02.018 |
Pubmed ID | |
Authors |
Panagiotis Ntziachristos, Jing Shan Lim, Julien Sage, Iannis Aifantis |
Abstract |
Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago, Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a variety of organisms and tissues. However, in the past 20 years, accumulating evidence has linked alterations in the Notch pathway to tumorigenesis. In this review, we discuss the protumorigenic and tumor-suppressive functions of Notch signaling, and dissect the molecular mechanisms that underlie these functions in hematopoietic cancers and solid tumors. Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 50% |
Brazil | 1 | 8% |
France | 1 | 8% |
United Kingdom | 1 | 8% |
Unknown | 3 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 58% |
Scientists | 4 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 2% |
Sweden | 2 | <1% |
United Kingdom | 2 | <1% |
Spain | 2 | <1% |
China | 1 | <1% |
Italy | 1 | <1% |
Greece | 1 | <1% |
Portugal | 1 | <1% |
Unknown | 341 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 86 | 24% |
Researcher | 82 | 23% |
Student > Master | 37 | 10% |
Student > Bachelor | 29 | 8% |
Other | 18 | 5% |
Other | 47 | 13% |
Unknown | 58 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 122 | 34% |
Biochemistry, Genetics and Molecular Biology | 95 | 27% |
Medicine and Dentistry | 36 | 10% |
Engineering | 7 | 2% |
Chemistry | 5 | 1% |
Other | 22 | 6% |
Unknown | 70 | 20% |