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From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

Overview of attention for article published in Cancer Cell, March 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (91st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

blogs
1 blog
twitter
12 X users
patent
1 patent

Citations

dimensions_citation
323 Dimensions

Readers on

mendeley
357 Mendeley
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Title
From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling
Published in
Cancer Cell, March 2014
DOI 10.1016/j.ccr.2014.02.018
Pubmed ID
Authors

Panagiotis Ntziachristos, Jing Shan Lim, Julien Sage, Iannis Aifantis

Abstract

Since Notch phenotypes in Drosophila melanogaster were first identified 100 years ago, Notch signaling has been extensively characterized as a regulator of cell-fate decisions in a variety of organisms and tissues. However, in the past 20 years, accumulating evidence has linked alterations in the Notch pathway to tumorigenesis. In this review, we discuss the protumorigenic and tumor-suppressive functions of Notch signaling, and dissect the molecular mechanisms that underlie these functions in hematopoietic cancers and solid tumors. Finally, we link these mechanisms and observations to possible therapeutic strategies targeting the Notch pathway in human cancers.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 357 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 6 2%
Sweden 2 <1%
United Kingdom 2 <1%
Spain 2 <1%
China 1 <1%
Italy 1 <1%
Greece 1 <1%
Portugal 1 <1%
Unknown 341 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 86 24%
Researcher 82 23%
Student > Master 37 10%
Student > Bachelor 29 8%
Other 18 5%
Other 47 13%
Unknown 58 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 122 34%
Biochemistry, Genetics and Molecular Biology 95 27%
Medicine and Dentistry 36 10%
Engineering 7 2%
Chemistry 5 1%
Other 22 6%
Unknown 70 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2020.
All research outputs
#2,050,546
of 25,374,917 outputs
Outputs from Cancer Cell
#1,325
of 3,149 outputs
Outputs of similar age
#20,376
of 236,354 outputs
Outputs of similar age from Cancer Cell
#16
of 39 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,149 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.3. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,354 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.