| Title |
The Mechanism Behind Top-Down UVPD Experiments: Making Sense of Apparent Contradictions
|
|---|---|
| Published in |
Journal of the American Society for Mass Spectrometry, July 2017
|
| DOI | 10.1007/s13361-017-1721-0 |
| Pubmed ID | |
| Authors |
Ryan R. Julian |
| Abstract |
Top-down ultraviolet photodissociation (UVPD) allows greater sequence coverage than any other currently available method, often fracturing the vast majority of peptide bonds in whole proteins. At the same time, UVPD can be used to dissociate noncovalent complexes assembled from multiple proteins without breaking any covalent bonds. Although the utility of these experiments is unquestioned, the mechanism underlying these seemingly contradictory results has been the subject of many discussions. Herein, some fundamental considerations of photochemistry are briefly summarized within the context of a proposed mechanism that rationalizes the experimental results obtained by UVPD. Considerations for future instrument design, in terms of wavelength choice and power, are briefly discussed. Graphical Abstract ᅟ. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 83 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 22% |
| Student > Master | 15 | 18% |
| Researcher | 10 | 12% |
| Student > Bachelor | 7 | 8% |
| Professor | 6 | 7% |
| Other | 15 | 18% |
| Unknown | 12 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 45 | 54% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Agricultural and Biological Sciences | 2 | 2% |
| Computer Science | 2 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
| Other | 7 | 8% |
| Unknown | 15 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2021.
All research outputs
#7,962,193
of 25,382,440 outputs
Outputs from Journal of the American Society for Mass Spectrometry
#1,097
of 3,835 outputs
Outputs of similar age
#116,287
of 324,886 outputs
Outputs of similar age from Journal of the American Society for Mass Spectrometry
#18
of 71 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,835 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 324,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 71 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.