Title |
Molecular Characterization of Carbapenemase-Producing Escherichia coli and Klebsiella pneumoniae in the Countries of the Gulf Cooperation Council: Dominance of OXA-48 and NDM Producers
|
---|---|
Published in |
Antimicrobial Agents and Chemotherapy, March 2014
|
DOI | 10.1128/aac.02050-13 |
Pubmed ID | |
Authors |
Hosam M. Zowawi, Anna L. Sartor, Hanan H. Balkhy, Timothy R. Walsh, Sameera M. Al Johani, Reem Y. AlJindan, Mubarak Alfaresi, Emad Ibrahim, Amina Al-Jardani, Seif Al-Abri, Jameela Al Salman, Ali A. Dashti, Abdullah H. Kutbi, Sanmarié Schlebusch, Hanna E. Sidjabat, David L. Paterson |
Abstract |
The molecular epidemiology and mechanisms of resistance of carbapenem-resistant Enterobacteriaceae (CRE) were determined in hospitals in the countries of the Gulf Cooperation Council (GCC), namely, Saudi Arabia, United Arab Emirates, Oman, Qatar, Bahrain, and Kuwait. Isolates were subjected to PCR-based detection of antibiotic-resistant genes and repetitive sequence-based PCR (rep-PCR) assessments of clonality. Sixty-two isolates which screened positive for potential carbapenemase production were assessed, and 45 were found to produce carbapenemase. The most common carbapenemases were of the OXA-48 (35 isolates) and NDM (16 isolates) types; 6 isolates were found to coproduce the OXA-48 and NDM types. No KPC-type, VIM-type, or IMP-type producers were detected. Multiple clones were detected with seven clusters of clonally related Klebsiella pneumoniae. Awareness of CRE in GCC countries has important implications for controlling the spread of CRE in the Middle East and in hospitals accommodating patients transferred from the region. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 14% |
United States | 1 | 14% |
United Kingdom | 1 | 14% |
Unknown | 4 | 57% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 57% |
Practitioners (doctors, other healthcare professionals) | 2 | 29% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Malaysia | 1 | <1% |
United States | 1 | <1% |
Nigeria | 1 | <1% |
Germany | 1 | <1% |
Unknown | 135 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 25 | 18% |
Student > Master | 20 | 14% |
Student > Ph. D. Student | 15 | 11% |
Student > Postgraduate | 10 | 7% |
Student > Bachelor | 7 | 5% |
Other | 28 | 20% |
Unknown | 34 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 27 | 19% |
Biochemistry, Genetics and Molecular Biology | 23 | 17% |
Medicine and Dentistry | 16 | 12% |
Agricultural and Biological Sciences | 15 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
Other | 10 | 7% |
Unknown | 40 | 29% |