Title |
Neuroimmunity of HTLV-I Infection
|
---|---|
Published in |
Journal of Neuroimmune Pharmacology, May 2010
|
DOI | 10.1007/s11481-010-9216-9 |
Pubmed ID | |
Authors |
Eiji Matsuura, Yoshihisa Yamano, Steven Jacobson |
Abstract |
Human T-lymphotrophic virus type I (HTLV-I) is an oncogenic retrovirus and its infection is associated with a variety of human diseases including HTLV-I-associated myelopathy/tropic spastic paraparesis (HAM/TSP). Large numbers of epidemiological, virological, immunological, and clinical studies on HTLV-I- and HTLV-I-associated diseases have been published, although the pathogenesis of HAM/TSP remains to be fully understood. In the last several years, researchers have shown that several key factors are important in HTLV-I-associated neurologic disease including high HTLV-I proviral load and a strong immune response to HTLV-I. Here, we review pathophysiological findings on HAM/TSP and focus on viral-host immune responses to the virus in HTLV-I infected individuals. In particular, the role of HTLV-I-specific CD8+ T cell response is highlighted. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 15% |
Student > Bachelor | 7 | 15% |
Student > Master | 6 | 13% |
Researcher | 5 | 10% |
Student > Doctoral Student | 3 | 6% |
Other | 12 | 25% |
Unknown | 8 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 31% |
Agricultural and Biological Sciences | 8 | 17% |
Immunology and Microbiology | 6 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Neuroscience | 2 | 4% |
Other | 5 | 10% |
Unknown | 9 | 19% |