| Title |
Selective IgA Deficiency in Autoimmune Diseases
|
|---|---|
| Published in |
Molecular Medicine, August 2011
|
| DOI | 10.2119/molmed.2011.00195 |
| Pubmed ID | |
| Authors |
Ning Wang, Nan Shen, Timothy J. Vyse, Vidya Anand, Iva Gunnarson, Gunnar Sturfelt, Solbritt Rantapää-Dahlqvist, Kerstin Elvin, Lennart Truedsson, Bengt A. Andersson, Charlotte Dahle, Eva Örtqvist, Peter K. Gregersen, Timothy W. Behrens, Lennart Hammarström |
| Abstract |
Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been reported. In addition, non-MHC genes, such as interferon-induced helicase 1 (IFIH1) and c-type lectin domain family 16, member A (CLEC16A), are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Australia | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 1% |
| Colombia | 1 | <1% |
| Switzerland | 1 | <1% |
| Hungary | 1 | <1% |
| Chile | 1 | <1% |
| Saint Kitts and Nevis | 1 | <1% |
| Brazil | 1 | <1% |
| France | 1 | <1% |
| Unknown | 166 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 30 | 17% |
| Researcher | 29 | 17% |
| Student > Ph. D. Student | 15 | 9% |
| Student > Doctoral Student | 15 | 9% |
| Student > Bachelor | 15 | 9% |
| Other | 42 | 24% |
| Unknown | 29 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 68 | 39% |
| Agricultural and Biological Sciences | 27 | 15% |
| Immunology and Microbiology | 14 | 8% |
| Biochemistry, Genetics and Molecular Biology | 13 | 7% |
| Social Sciences | 4 | 2% |
| Other | 17 | 10% |
| Unknown | 32 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2023.
All research outputs
#2,611,823
of 25,655,374 outputs
Outputs from Molecular Medicine
#73
of 1,208 outputs
Outputs of similar age
#12,320
of 131,099 outputs
Outputs of similar age from Molecular Medicine
#1
of 11 outputs
Altmetric has tracked 25,655,374 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,208 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 93% of its peers.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.