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S100 to receptor for advanced glycation end-products binding assay: Looking for inhibitors

Overview of attention for article published in Biochemical & Biophysical Research Communications, March 2014
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (79th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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1 X user
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2 patents

Citations

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11 Dimensions

Readers on

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21 Mendeley
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1 CiteULike
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Title
S100 to receptor for advanced glycation end-products binding assay: Looking for inhibitors
Published in
Biochemical & Biophysical Research Communications, March 2014
DOI 10.1016/j.bbrc.2014.02.143
Pubmed ID
Authors

Laura Padilla, Sheila Dakhel, Jose Luis Hernández

Abstract

Secreted by tumor and stromal cells, S100 proteins exert their biological functions via the interaction with surface receptors. The most described receptor is the receptor for advanced glycation end-products (RAGE), thereby participating in the S100-dependent cell migration, invasion, tumor growth, angiogenesis and metastasis. Several approaches have been described for determining this interaction. Here we describe an easy, specific and highly reproducible ELISA-based method, by optimizing several parameters such as the binding and blocking buffer, interaction time and concentrations, directed to screen chemical and biological inhibitors of this interaction for S100A4, S100A7 and S100P proteins. The efficiency of the protocol was validated by using well described neutralizing agents of the RAGE receptor and of the S100A4 activity. The methodology described here will allow future works with other members of the S100 protein family and their receptors.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 24%
Other 3 14%
Student > Doctoral Student 3 14%
Professor 2 10%
Student > Master 2 10%
Other 4 19%
Unknown 2 10%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Biochemistry, Genetics and Molecular Biology 4 19%
Agricultural and Biological Sciences 4 19%
Physics and Astronomy 2 10%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 1 5%
Unknown 3 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2020.
All research outputs
#5,240,751
of 25,374,917 outputs
Outputs from Biochemical & Biophysical Research Communications
#2,940
of 26,637 outputs
Outputs of similar age
#48,298
of 235,687 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#19
of 166 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,637 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,687 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 166 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.