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How Mycobacterium tuberculosis goes to sleep: the dormancy survival regulator DosR a decade later

Overview of attention for article published in Future Microbiology, April 2012
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

blogs
1 blog

Citations

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80 Dimensions

Readers on

mendeley
116 Mendeley
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Title
How Mycobacterium tuberculosis goes to sleep: the dormancy survival regulator DosR a decade later
Published in
Future Microbiology, April 2012
DOI 10.2217/fmb.12.14
Pubmed ID
Authors

Calvin Boon, Thomas Dick

Abstract

With 2 million deaths per year, TB remains the most significant bacterial killer. The long duration of chemotherapy and the large pool of latently infected people represent challenges in disease control. To develop drugs that effectively eradicate latent infection and shorten treatment duration, the pathophysiology of the causative agent Mycobacterium tuberculosis needs to be understood. The discovery that the tubercle bacillus can develop a drug-tolerant dormant form and the identification of the underlying genetic program 10 years ago paved the way for a deeper understanding of the life of the parasite inside human lesions and for new approaches to antimycobacterial drug discovery. Here, we summarize what we have learnt since the discovery of the master regulator of dormancy, DosR, and the key gaps in our knowledge that remain. Furthermore, we discuss a possible wider clinical relevance of DosR for 'nontuberculous mycobacteria'.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 116 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Canada 1 <1%
New Zealand 1 <1%
United States 1 <1%
Philippines 1 <1%
Unknown 111 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 20%
Researcher 23 20%
Student > Bachelor 9 8%
Student > Master 9 8%
Professor 7 6%
Other 18 16%
Unknown 27 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 29%
Medicine and Dentistry 14 12%
Biochemistry, Genetics and Molecular Biology 14 12%
Immunology and Microbiology 11 9%
Chemistry 6 5%
Other 9 8%
Unknown 28 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2014.
All research outputs
#5,870,960
of 22,749,166 outputs
Outputs from Future Microbiology
#279
of 1,364 outputs
Outputs of similar age
#39,443
of 160,954 outputs
Outputs of similar age from Future Microbiology
#5
of 14 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,364 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 160,954 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.