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A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit

Overview of attention for article published in JAMA Neurology, May 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
2 news outlets
twitter
32 X users
facebook
2 Facebook pages

Citations

dimensions_citation
289 Dimensions

Readers on

mendeley
381 Mendeley
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Title
A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit
Published in
JAMA Neurology, May 2014
DOI 10.1001/jamaneurol.2014.131
Pubmed ID
Authors

M. Flint Beal, David Oakes, Ira Shoulson, Claire Henchcliffe, Wendy R. Galpern, Richard Haas, Jorge L. Juncos, John G. Nutt, Tiffini Smith Voss, Bernard Ravina, Clifford M. Shults, Karen Helles, Victoria Snively, Mark F. Lew, Brian Griebner, Arthur Watts, Shan Gao, Emmanuelle Pourcher, Louisette Bond, Katie Kompoliti, Pinky Agarwal, Cherissa Sia, Mandar Jog, Linda Cole, Munira Sultana, Roger Kurlan, Irene Richard, Cheryl Deeley, Cheryl H. Waters, Angel Figueroa, Ani Arkun, Matthew Brodsky, William G. Ondo, Christine B. Hunter, Joohi Jimenez-Shahed, Alicia Palao, Janis M. Miyasaki, Julie So, James Tetrud, Liza Reys, Katharine Smith, Carlos Singer, Anita Blenke, David S. Russell, Candace Cotto, Joseph H. Friedman, Margaret Lannon, Lin Zhang, Edward Drasby, Rajeev Kumar, Thyagarajan Subramanian, Donna Stuppy Ford, David A. Grimes, Diane Cote, Jennifer Conway, Andrew D. Siderowf, Marian Leslie Evatt, Barbara Sommerfeld, Abraham N. Lieberman, Michael S. Okun, Ramon L. Rodriguez, Stacy Merritt, Camille Louise Swartz, W. R. Wayne Martin, Pamela King, Natividad Stover, Stephanie Guthrie, Ray L. Watts, Anwar Ahmed, Hubert H. Fernandez, Adrienna Winters, Zoltan Mari, Ted M. Dawson, Becky Dunlop, Andrew S. Feigin, Barbara Shannon, Melissa Jill Nirenberg, Mattson Ogg, Samuel A. Ellias, Cathi-Ann Thomas, Karen Frei, Ivan Bodis-Wollner, Sofya Glazman, Thomas Mayer, Robert A. Hauser, Rajesh Pahwa, April Langhammer, Ranjit Ranawaya, Lorelei Derwent, Kapil D. Sethi, Buff Farrow, Rajan Prakash, Irene Litvan, Annette Robinson, Alok Sahay, Maureen Gartner, Vanessa K. Hinson, Samuel Markind, Melisa Pelikan, Joel S. Perlmutter, Johanna Hartlein, Eric Molho, Sharon Evans, Charles H. Adler, Amy Duffy, Marlene Lind, Lawrence Elmer, Kathy Davis, Julia Spears, Stephanie Wilson, Maureen A. Leehey, Neal Hermanowicz, Shari Niswonger, Holly A. Shill, Sanja Obradov, Alex Rajput, Marilyn Cowper, Stephanie Lessig, David Song, Deborah Fontaine, Cindy Zadikoff, Karen Williams, Karen A. Blindauer, Jo Bergholte, Clara Schindler Propsom, Mark A. Stacy, Joanne Field, Dragos Mihaila, Mark Chilton, Ergun Y. Uc, Jeri Sieren, David K. Simon, Lauren Kraics, Althea Silver, James T. Boyd, Robert W. Hamill, Christopher Ingvoldstad, Jennifer Young, Karen Thomas, Sandra K. Kostyk, Joanne Wojcieszek, Ronald F. Pfeiffer, Michel Panisset, Monica Beland, Stephen G. Reich, Michelle Cines, Nancy Zappala, Jean Rivest, Richard Zweig, L. Pepper Lumina, Colette Lynn Hilliard, Stephen Grill, Marye Kellermann, Paul Tuite, Susan Rolandelli, Un Jung Kang, Joan Young, Jayaraman Rao, Maureen M. Cook, Lawrence Severt, Karyn Boyar

Abstract

Coenzyme Q10 (CoQ10), an antioxidant that supports mitochondrial function, has been shown in preclinical Parkinson disease (PD) models to reduce the loss of dopamine neurons, and was safe and well tolerated in early-phase human studies. A previous phase II study suggested possible clinical benefit.

X Demographics

X Demographics

The data shown below were collected from the profiles of 32 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 381 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 <1%
Austria 1 <1%
Brazil 1 <1%
United Kingdom 1 <1%
Egypt 1 <1%
United States 1 <1%
Unknown 375 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 54 14%
Researcher 52 14%
Student > Ph. D. Student 47 12%
Student > Bachelor 36 9%
Other 23 6%
Other 75 20%
Unknown 94 25%
Readers by discipline Count As %
Medicine and Dentistry 88 23%
Neuroscience 40 10%
Agricultural and Biological Sciences 37 10%
Nursing and Health Professions 27 7%
Biochemistry, Genetics and Molecular Biology 16 4%
Other 59 15%
Unknown 114 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2019.
All research outputs
#1,023,349
of 25,513,063 outputs
Outputs from JAMA Neurology
#1,218
of 5,868 outputs
Outputs of similar age
#9,770
of 242,426 outputs
Outputs of similar age from JAMA Neurology
#8
of 88 outputs
Altmetric has tracked 25,513,063 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,868 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.3. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,426 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.