| Title |
Cytotoxic activity evaluation and QSAR study of chromene-based chalcones
|
|---|---|
| Published in |
Archives of Pharmacal Research, December 2012
|
| DOI | 10.1007/s12272-012-1208-2 |
| Pubmed ID | |
| Authors |
Loghman Firoozpour, Najmeh Edraki, Maryam Nakhjiri, Saeed Emami, Maliheh Safavi, Sussan Kabudanian Ardestani, Mehdi Khoshneviszadeh, Abbas Shafiee, Alireza Foroumadi |
| Abstract |
Chalcone and chromene motifs are synthetic or naturally occurring scaffolds with significant cytotoxic profile. Two types of novel regioisomeric chromene-chalcone hybrids, namely 1-(6-chloro or 6-methoxy-2H-chromen-3-yl)-3-phenylprop-2-en-1-one (Type A) and 3-(6-chloro or 6-methoxy-2H-chromen-3-yl)-1-phenylprop-2-en-1-one (Type B), both with different substituents on the phenyl ring attached to propenone linkage, have been evaluated for their cytotoxic activity against breast cancer cell lines (MCF-7 and MDA-MB-231). The results indicate that type A of chromene-chalcones demonstrated better cytotoxic profile than type B especially in MDA-MB-231 cell line. In addition, the growth inhibitory activity of most of the target compounds is higher than Etoposide as a reference drug. QSAR analysis of these novel compounds demonstrated that topological and geometrical parameters are among the important descriptors that influence the cytotoxic activity profile of compounds. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 16% |
| Student > Doctoral Student | 5 | 16% |
| Professor | 3 | 9% |
| Student > Ph. D. Student | 3 | 9% |
| Researcher | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 8 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 28% |
| Biochemistry, Genetics and Molecular Biology | 5 | 16% |
| Agricultural and Biological Sciences | 3 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 9% |
| Medicine and Dentistry | 3 | 9% |
| Other | 1 | 3% |
| Unknown | 8 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2014.
All research outputs
#20,224,618
of 22,749,166 outputs
Outputs from Archives of Pharmacal Research
#1,134
of 1,294 outputs
Outputs of similar age
#248,540
of 280,232 outputs
Outputs of similar age from Archives of Pharmacal Research
#21
of 21 outputs
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