| Title |
Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer’s disease: a coordinate-based meta-analysis
|
|---|---|
| Published in |
Brain Structure and Function, March 2014
|
| DOI | 10.1007/s00429-014-0744-6 |
| Pubmed ID | |
| Authors |
Nils Nellessen, Claudia Rottschy, Simon B. Eickhoff, Simon T. Ketteler, Hanna Kuhn, N. Jon Shah, Jörg B. Schulz, Martina Reske, Kathrin Reetz |
| Abstract |
Episodic memory is typically affected during the course of Alzheimer's disease (AD). Due to the pronounced heterogeneity of functional neuroimaging studies on episodic memory impairments in mild cognitive impairment (MCI) and AD regarding their methodology and findings, we aimed to delineate consistent episodic memory-related brain activation patterns. We performed a systematic, quantitative, coordinate-based whole-brain activation likelihood estimation meta-analysis of 28 functional magnetic resonance imaging (fMRI) studies comprising 292 MCI and 102 AD patients contrasted to 409 age-matched control subjects. We included episodic encoding and/or retrieval phases, investigated the effects of group, verbal or image stimuli and correlated mean Mini-Mental-Status-Examination (MMSE) scores with the modelled activation estimates. MCI patients presented increased right hippocampal activation during memory encoding, decreased activation in the left hippocampus and fusiform gyrus during retrieval tasks, as well as attenuated activation in the right anterior insula/inferior frontal gyrus during verbal retrieval. In AD patients, however, stronger activation within the precuneus during encoding tasks was accompanied by attenuated right hippocampal activation during retrieval tasks. Low cognitive performance (MMSE scores) was associated with stronger activation of the precuneus and reduced activation of the right (para)hippocampus and anterior insula/inferior frontal gyrus. This meta-analysis provides evidence for a specific and probably disease stage-dependent brain activation pattern related to the pathognomonic AD characteristic of episodic memory loss. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| Austria | 1 | 1% |
| Unknown | 95 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 13% |
| Student > Ph. D. Student | 11 | 11% |
| Student > Master | 11 | 11% |
| Student > Bachelor | 10 | 10% |
| Student > Doctoral Student | 5 | 5% |
| Other | 18 | 19% |
| Unknown | 29 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 27 | 28% |
| Medicine and Dentistry | 13 | 13% |
| Neuroscience | 8 | 8% |
| Nursing and Health Professions | 5 | 5% |
| Agricultural and Biological Sciences | 4 | 4% |
| Other | 8 | 8% |
| Unknown | 32 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 March 2014.
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#19,702,729
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Outputs from Brain Structure and Function
#1,236
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#166,052
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Outputs of similar age from Brain Structure and Function
#20
of 29 outputs
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