| Title |
Oxidative stress in Alzheimer’s disease
|
|---|---|
| Published in |
Neuroscience Bulletin, March 2014
|
| DOI | 10.1007/s12264-013-1423-y |
| Pubmed ID | |
| Authors |
Zhichun Chen, Chunjiu Zhong |
| Abstract |
Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a devastating disease of the elderly. The brain is more vulnerable than other organs to oxidative stress, and most of the components of neurons (lipids, proteins, and nucleic acids) can be oxidized in AD due to mitochondrial dysfunction, increased metal levels, inflammation, and β-amyloid (Aβ) peptides. Oxidative stress participates in the development of AD by promoting Aβ deposition, tau hyperphosphorylation, and the subsequent loss of synapses and neurons. The relationship between oxidative stress and AD suggests that oxidative stress is an essential part of the pathological process, and antioxidants may be useful for AD treatment. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 798 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 3 | <1% |
| India | 1 | <1% |
| Malaysia | 1 | <1% |
| Mexico | 1 | <1% |
| Chile | 1 | <1% |
| Unknown | 787 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 121 | 15% |
| Student > Ph. D. Student | 115 | 14% |
| Student > Master | 91 | 11% |
| Researcher | 59 | 7% |
| Student > Doctoral Student | 32 | 4% |
| Other | 92 | 12% |
| Unknown | 288 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 109 | 14% |
| Agricultural and Biological Sciences | 90 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 65 | 8% |
| Neuroscience | 63 | 8% |
| Medicine and Dentistry | 62 | 8% |
| Other | 106 | 13% |
| Unknown | 303 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2014.
All research outputs
#14,777,143
of 22,749,166 outputs
Outputs from Neuroscience Bulletin
#343
of 761 outputs
Outputs of similar age
#126,035
of 223,836 outputs
Outputs of similar age from Neuroscience Bulletin
#8
of 14 outputs
Altmetric has tracked 22,749,166 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 761 research outputs from this source. They receive a mean Attention Score of 4.0. This one has gotten more attention than average, scoring higher than 52% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 35th percentile – i.e., 35% of its contemporaries scored the same or lower than it.