| Title |
Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances
|
|---|---|
| Published in |
Archives of Toxicology, June 2011
|
| DOI | 10.1007/s00204-011-0726-x |
| Pubmed ID | |
| Authors |
David M. Soderlund |
| Abstract |
Synthetic pyrethroid insecticides were introduced into widespread use for the control of insect pests and disease vectors more than three decades ago. In addition to their value in controlling agricultural pests, pyrethroids are at the forefront of efforts to combat malaria and other mosquito-borne diseases and are also common ingredients of household insecticide and companion animal ectoparasite control products. The abundance and variety of pyrethroid uses contribute to the risk of exposure and adverse effects in the general population. The insecticidal actions of pyrethroids depend on their ability to bind to and disrupt voltage-gated sodium channels of insect nerves. Sodium channels are also important targets for the neurotoxic effects of pyrethroids in mammals but other targets, particularly voltage-gated calcium and chloride channels, have been implicated as alternative or secondary sites of action for a subset of pyrethroids. This review summarizes information published during the past decade on the action of pyrethroids on voltage-gated sodium channels as well as on voltage-gated calcium and chloride channels and provides a critical re-evaluation of the role of these three targets in pyrethroid neurotoxicity based on this information. |
Mendeley readers
The data shown below were compiled from readership statistics for 444 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| United Kingdom | 2 | <1% |
| Germany | 1 | <1% |
| Pakistan | 1 | <1% |
| Brazil | 1 | <1% |
| Japan | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 433 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 62 | 14% |
| Student > Ph. D. Student | 61 | 14% |
| Student > Bachelor | 50 | 11% |
| Researcher | 45 | 10% |
| Student > Doctoral Student | 19 | 4% |
| Other | 70 | 16% |
| Unknown | 137 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 107 | 24% |
| Biochemistry, Genetics and Molecular Biology | 46 | 10% |
| Environmental Science | 27 | 6% |
| Medicine and Dentistry | 25 | 6% |
| Chemistry | 24 | 5% |
| Other | 65 | 15% |
| Unknown | 150 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 29. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2022.
All research outputs
#1,158,758
of 22,994,508 outputs
Outputs from Archives of Toxicology
#63
of 2,652 outputs
Outputs of similar age
#4,906
of 116,242 outputs
Outputs of similar age from Archives of Toxicology
#1
of 13 outputs
Altmetric has tracked 22,994,508 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,652 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,242 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.