Title |
Improving MEME via a two-tiered significance analysis
|
---|---|
Published in |
Bioinformatics, March 2014
|
DOI | 10.1093/bioinformatics/btu163 |
Pubmed ID | |
Authors |
Emi Tanaka, Timothy L Bailey, Uri Keich |
Abstract |
With over 9000 unique users recorded in the first half of 2013, MEME is one of the most popular motif-finding tools available. Reliable estimates of the statistical significance of motifs can greatly increase the usefulness of any motif finder. By analogy, it is difficult to imagine evaluating a BLAST result without its accompanying E-value. Currently MEME evaluates its EM-generated candidate motifs using an extension of BLAST's E-value to the motif-finding context. Although we previously indicated the drawbacks of MEME's current significance evaluation, we did not offer a practical substitute suited for its needs, especially because MEME also relies on the E-value internally to rank competing candidate motifs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 33% |
Norway | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 5 | 83% |
Members of the public | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 7% |
France | 2 | 4% |
Japan | 1 | 2% |
Norway | 1 | 2% |
Unknown | 38 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 27% |
Student > Ph. D. Student | 10 | 22% |
Student > Master | 5 | 11% |
Student > Bachelor | 4 | 9% |
Professor | 4 | 9% |
Other | 6 | 13% |
Unknown | 4 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 22 | 49% |
Biochemistry, Genetics and Molecular Biology | 10 | 22% |
Computer Science | 5 | 11% |
Mathematics | 1 | 2% |
Arts and Humanities | 1 | 2% |
Other | 1 | 2% |
Unknown | 5 | 11% |