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Mendeley readers
Attention Score in Context
| Title |
Anti-cooperative ligand binding and dimerisation in the glycopeptide antibiotic dalbavancin
|
|---|---|
| Published in |
Organic and Biomolecular Chemistry, January 2014
|
| DOI | 10.1039/c3ob42428f |
| Pubmed ID | |
| Authors |
Mu Cheng, Zyta M. Ziora, Karl A. Hansford, Mark A. Blaskovich, Mark S. Butler, Matthew A. Cooper |
| Abstract |
Dalbavancin, a semi-synthetic glycopeptide with enhanced antibiotic activity compared to vancomycin and teicoplanin, binds to the C-terminal lysyl-d-alanyl-d-alanine subunit of Lipid II, inhibiting peptidoglycan biosynthesis. In this study, micro-calorimetry and electrospray ionization (ESI)-MS have been used to investigate the relationship between oligomerisation of dalbavancin and binding of a Lipid II peptide mimic, diacetyl-Lys-d-Ala-d-Ala (Ac2-Kaa). Dalbavancin dimerised strongly in an anti-cooperative manner with ligand-binding, as was the case for ristocetin A, but not for vancomycin and teicoplanin. Dalbavancin and ristocetin A both adopt an 'closed' conformation upon ligand binding, suggesting anti-cooperative dimerisation with ligand-binding may be a general feature of dalbavancin/ristocetin A-like glycopeptides. Understanding these effects may provide insight into design of novel dalbavancin derivatives with cooperative ligand-binding and dimerisation characteristics that could enhance antibiotic activity. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 31% |
| Student > Bachelor | 5 | 14% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Postgraduate | 4 | 11% |
| Student > Master | 3 | 8% |
| Other | 2 | 6% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 28% |
| Chemistry | 6 | 17% |
| Agricultural and Biological Sciences | 6 | 17% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Medicine and Dentistry | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2014.
All research outputs
#6,884,964
of 25,756,911 outputs
Outputs from Organic and Biomolecular Chemistry
#1,743
of 6,872 outputs
Outputs of similar age
#73,583
of 321,307 outputs
Outputs of similar age from Organic and Biomolecular Chemistry
#87
of 326 outputs
Altmetric has tracked 25,756,911 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 6,872 research outputs from this source. They receive a mean Attention Score of 3.7. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 321,307 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 326 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.