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Alternatively activated macrophages as therapeutic agents for kidney disease: in vivo stability is a key factor

Overview of attention for article published in Kidney International, April 2014
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Title
Alternatively activated macrophages as therapeutic agents for kidney disease: in vivo stability is a key factor
Published in
Kidney International, April 2014
DOI 10.1038/ki.2013.405
Pubmed ID
Authors

Senthilkumar Alagesan, Matthew D. Griffin

Abstract

Infusing ex vivo-generated alternatively activated macrophages (AAM) has shown promise in experimental systems as a therapeutic strategy for inflammatory kidney disease. In the mouse Adriamycin nephropathy model, however, Cao et al. report that AAM derived from bone marrow precursors fail to ameliorate disease severity. Absence of the anticipated protective effect resulted from a loss of macrophage anti-inflammatory (M2) phenotype following trafficking to injured kidney-an effect that was mediated by localized colony-stimulating factor-1-dependent macrophage proliferation.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 34%
Student > Bachelor 6 15%
Student > Master 4 10%
Researcher 3 7%
Other 3 7%
Other 6 15%
Unknown 5 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 24%
Medicine and Dentistry 8 20%
Biochemistry, Genetics and Molecular Biology 6 15%
Immunology and Microbiology 6 15%
Engineering 3 7%
Other 2 5%
Unknown 6 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2014.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Kidney International
#6,757
of 7,405 outputs
Outputs of similar age
#176,006
of 239,197 outputs
Outputs of similar age from Kidney International
#55
of 66 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,405 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 239,197 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.