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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology
|
|---|---|
| Published in |
Neurobiology of Aging, March 2014
|
| DOI | 10.1016/j.neurobiolaging.2014.03.027 |
| Pubmed ID | |
| Authors |
Cyril Laurent, Sabiha Eddarkaoui, Maxime Derisbourg, Antoine Leboucher, Dominique Demeyer, Sébastien Carrier, Marion Schneider, Malika Hamdane, Christa E. Müller, Luc Buée, David Blum |
| Abstract |
Tau pathology found in Alzheimer's disease (AD) is crucial in cognitive decline. Epidemiologic evidences support that habitual caffeine intake prevents memory decline during aging and reduces the risk to develop Alzheimer's disease. So far, experimental studies addressed the impact of caffeine in models mimicking the amyloid pathology of AD. However, in vivo effects of caffeine in a model of AD-like tauopathy remain unknown. Here, we evaluated effects of chronic caffeine intake (0.3 g/L through drinking water), given at an early pathologic stage, in the THY-Tau22 transgenic mouse model of progressive AD-like tau pathology. We found that chronic caffeine intake prevents from the development of spatial memory deficits in tau mice. Improved memory was associated with reduced hippocampal tau phosphorylation and proteolytic fragments. Moreover, caffeine treatment mitigated several proinflammatory and oxidative stress markers found upregulated in the hippocampus of THY-Tau22 animals. Together, our data support that moderate caffeine intake is beneficial in a model of AD-like tau pathology, paving the way for future clinical evaluation in AD patients. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 8 | 26% |
| United Kingdom | 2 | 6% |
| Chile | 1 | 3% |
| Lebanon | 1 | 3% |
| Spain | 1 | 3% |
| France | 1 | 3% |
| Australia | 1 | 3% |
| Mexico | 1 | 3% |
| Italy | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 13 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 21 | 68% |
| Scientists | 7 | 23% |
| Practitioners (doctors, other healthcare professionals) | 2 | 6% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Mexico | 1 | <1% |
| Belgium | 1 | <1% |
| Spain | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 182 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 36 | 19% |
| Student > Ph. D. Student | 28 | 15% |
| Researcher | 26 | 14% |
| Student > Master | 23 | 12% |
| Student > Doctoral Student | 10 | 5% |
| Other | 31 | 16% |
| Unknown | 34 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 19% |
| Neuroscience | 28 | 15% |
| Medicine and Dentistry | 23 | 12% |
| Biochemistry, Genetics and Molecular Biology | 15 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 13 | 7% |
| Other | 32 | 17% |
| Unknown | 42 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 186. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2024.
All research outputs
#216,852
of 25,547,904 outputs
Outputs from Neurobiology of Aging
#27
of 4,432 outputs
Outputs of similar age
#1,731
of 238,989 outputs
Outputs of similar age from Neurobiology of Aging
#2
of 54 outputs
Altmetric has tracked 25,547,904 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,432 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.6. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,989 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.