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Global dissemination of a multidrug resistant Escherichia coli clone

Overview of attention for article published in Proceedings of the National Academy of Sciences of the United States of America, March 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
3 news outlets
blogs
4 blogs
policy
1 policy source
twitter
45 X users

Citations

dimensions_citation
476 Dimensions

Readers on

mendeley
506 Mendeley
citeulike
3 CiteULike
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Title
Global dissemination of a multidrug resistant Escherichia coli clone
Published in
Proceedings of the National Academy of Sciences of the United States of America, March 2014
DOI 10.1073/pnas.1322678111
Pubmed ID
Authors

Nicola K. Petty, Nouri L. Ben Zakour, Mitchell Stanton-Cook, Elizabeth Skippington, Makrina Totsika, Brian M. Forde, Minh-Duy Phan, Danilo Gomes Moriel, Kate M. Peters, Mark Davies, Benjamin A. Rogers, Gordon Dougan, Jesús Rodriguez-Baño, Alvaro Pascual, Johann D. D. Pitout, Mathew Upton, David L. Paterson, Timothy R. Walsh, Mark A. Schembri, Scott A. Beatson

Abstract

Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and bloodstream infections. The rapid emergence and successful spread of E. coli ST131 is strongly associated with several factors, including resistance to fluoroquinolones, high virulence gene content, the possession of the type 1 fimbriae FimH30 allele, and the production of the CTX-M-15 extended spectrum β-lactamase (ESBL). Here, we used genome sequencing to examine the molecular epidemiology of a collection of E. coli ST131 strains isolated from six distinct geographical locations across the world spanning 2000-2011. The global phylogeny of E. coli ST131, determined from whole-genome sequence data, revealed a single lineage of E. coli ST131 distinct from other extraintestinal E. coli strains within the B2 phylogroup. Three closely related E. coli ST131 sublineages were identified, with little association to geographic origin. The majority of single-nucleotide variants associated with each of the sublineages were due to recombination in regions adjacent to mobile genetic elements (MGEs). The most prevalent sublineage of ST131 strains was characterized by fluoroquinolone resistance, and a distinct virulence factor and MGE profile. Four different variants of the CTX-M ESBL-resistance gene were identified in our ST131 strains, with acquisition of CTX-M-15 representing a defining feature of a discrete but geographically dispersed ST131 sublineage. This study confirms the global dispersal of a single E. coli ST131 clone and demonstrates the role of MGEs and recombination in the evolution of this important MDR pathogen.

X Demographics

X Demographics

The data shown below were collected from the profiles of 45 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 506 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 3 <1%
Germany 2 <1%
United States 2 <1%
United Kingdom 2 <1%
India 2 <1%
Denmark 2 <1%
Australia 1 <1%
France 1 <1%
Ecuador 1 <1%
Other 2 <1%
Unknown 488 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 87 17%
Student > Ph. D. Student 83 16%
Student > Master 62 12%
Student > Bachelor 59 12%
Student > Doctoral Student 33 7%
Other 85 17%
Unknown 97 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 127 25%
Biochemistry, Genetics and Molecular Biology 82 16%
Immunology and Microbiology 68 13%
Medicine and Dentistry 46 9%
Veterinary Science and Veterinary Medicine 15 3%
Other 54 11%
Unknown 114 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 76. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2019.
All research outputs
#536,999
of 24,625,114 outputs
Outputs from Proceedings of the National Academy of Sciences of the United States of America
#9,471
of 101,438 outputs
Outputs of similar age
#4,843
of 231,207 outputs
Outputs of similar age from Proceedings of the National Academy of Sciences of the United States of America
#149
of 1,001 outputs
Altmetric has tracked 24,625,114 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 101,438 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 38.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,207 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1,001 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.