Title |
The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats
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Published in |
BMC Bioinformatics, May 2007
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DOI | 10.1186/1471-2105-8-172 |
Pubmed ID | |
Authors |
Ibtissem Grissa, Gilles Vergnaud, Christine Pourcel |
Abstract |
In Archeae and Bacteria, the repeated elements called CRISPRs for "clustered regularly interspaced short palindromic repeats" are believed to participate in the defence against viruses. Short sequences called spacers are stored in-between repeated elements. In the current model, motifs comprising spacers and repeats may target an invading DNA and lead to its degradation through a proposed mechanism similar to RNA interference. Analysis of intra-species polymorphism shows that new motifs (one spacer and one repeated element) are added in a polarised fashion. Although their principal characteristics have been described, a lot remains to be discovered on the way CRISPRs are created and evolve. As new genome sequences become available it appears necessary to develop automated scanning tools to make available CRISPRs related information and to facilitate additional investigations. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 1% |
United Kingdom | 5 | <1% |
France | 4 | <1% |
Germany | 2 | <1% |
Denmark | 2 | <1% |
New Zealand | 2 | <1% |
Australia | 1 | <1% |
Brazil | 1 | <1% |
Netherlands | 1 | <1% |
Other | 6 | <1% |
Unknown | 872 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 193 | 21% |
Student > Master | 136 | 15% |
Student > Bachelor | 134 | 15% |
Researcher | 131 | 14% |
Student > Doctoral Student | 37 | 4% |
Other | 111 | 12% |
Unknown | 166 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 318 | 35% |
Biochemistry, Genetics and Molecular Biology | 241 | 27% |
Immunology and Microbiology | 45 | 5% |
Computer Science | 25 | 3% |
Medicine and Dentistry | 16 | 2% |
Other | 74 | 8% |
Unknown | 189 | 21% |