Title |
Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New “Leave Me Alone” Lesion with a Characteristic Imaging Pattern
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Published in |
American Journal of Neuroradiology, July 2017
|
DOI | 10.3174/ajnr.a5281 |
Pubmed ID | |
Authors |
R.H. Nunes, C.C. Hsu, A.J. da Rocha, L.L.F. do Amaral, L.F.S. Godoy, T.W. Watkins, V.H. Marussi, M. Warmuth-Metz, H.C. Alves, F.G. Goncalves, B.K. Kleinschmidt-DeMasters, A.G. Osborn |
Abstract |
Multinodular and vacuolating neuronal tumor of the cerebrum is a recently reported benign, mixed glial neuronal lesion that is included in the 2016 updated World Health Organization classification of brain neoplasms as a unique cytoarchitectural pattern of gangliocytoma. We report 33 cases of presumed multinodular and vacuolating neuronal tumor of the cerebrum that exhibit a remarkably similar pattern of imaging findings consisting of a subcortical cluster of nodular lesions located on the inner surface of an otherwise normal-appearing cortex, principally within the deep cortical ribbon and superficial subcortical white matter, which is hyperintense on FLAIR. Only 4 of our cases are biopsy-proven because most were asymptomatic and incidentally discovered. The remaining were followed for a minimum of 24 months (mean, 3 years) without interval change. We demonstrate that these are benign, nonaggressive lesions that do not require biopsy in asymptomatic patients and behave more like a malformative process than a true neoplasm. |
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Country | Count | As % |
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Spain | 9 | 15% |
India | 2 | 3% |
New Zealand | 2 | 3% |
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Netherlands | 1 | 2% |
United Arab Emirates | 1 | 2% |
France | 1 | 2% |
Ecuador | 1 | 2% |
Other | 5 | 8% |
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Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 15 | 25% |
Scientists | 8 | 14% |
Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 80 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 16 | 20% |
Researcher | 10 | 13% |
Professor > Associate Professor | 8 | 10% |
Student > Postgraduate | 7 | 9% |
Student > Doctoral Student | 5 | 6% |
Other | 15 | 19% |
Unknown | 19 | 24% |
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Unspecified | 3 | 4% |
Nursing and Health Professions | 2 | 3% |
Biochemistry, Genetics and Molecular Biology | 1 | 1% |
Other | 4 | 5% |
Unknown | 21 | 26% |