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Kinase Signaling Networks

Overview of attention for book
Cover of 'Kinase Signaling Networks'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Optogenetic Control of Ras/Erk Signaling Using the Phy–PIF System
  3. Altmetric Badge
    Chapter 2 Dissecting Kinase Effector Signaling Using the RapRTAP Methodology
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    Chapter 3 Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors
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    Chapter 4 Quantification of Cell Signaling Networks Using Kinase Activity Chemosensors
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    Chapter 5 Expression of Recombinant Phosphoproteins for Signal Transduction Studies
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    Chapter 6 Allosteric Modulation of Src Family Kinases with ATP-Competitive Inhibitors
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    Chapter 7 Characterization of Ligand Binding to Pseudokinases Using a Thermal Shift Assay
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    Chapter 8 Proteomic Profiling of Protein Kinase Inhibitor Targets by Mass Spectrometry
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    Chapter 9 Utilizing the Luminex Magnetic Bead-Based Suspension Array for Rapid Multiplexed Phosphoprotein Quantification
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    Chapter 10 High-Content Imaging and RNAi Screens for Investigating Kinase Network Plasticity
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    Chapter 11 Analysis of Drug Resistance Using Kinome-Wide Functional Screens
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    Chapter 12 Identification and Validation of Driver Kinases from Next-Generation Sequencing Data
  14. Altmetric Badge
    Chapter 13 Label-Free Phosphoproteomic Approach for Kinase Signaling Analysis
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    Chapter 14 Cell-Specific Labeling for Analyzing Bidirectional Signaling by Mass Spectrometry
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    Chapter 15 Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics
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    Chapter 16 Analysis of Phosphotyrosine Signaling Networks in Lung Cancer Cell Lines
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    Chapter 17 Targeted Analysis of Phosphotyrosine Signaling by Multiple Reaction Monitoring Mass Spectrometry
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    Chapter 18 Phosphoproteomic Analysis of Isolated Mitochondria in Yeast
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    Chapter 19 A Methodology for Comprehensive Analysis of Toll-Like Receptor Signaling in Macrophages
  21. Altmetric Badge
    Chapter 20 Absolute Phosphorylation Stoichiometry Analysis by Motif-Targeting Quantitative Mass Spectrometry
  22. Altmetric Badge
    Chapter 21 Identification of Plant Kinase Substrates Based on Kinase Assay-Linked Phosphoproteomics
  23. Altmetric Badge
    Chapter 22 Mass Spectrometry Analysis of Spatial Protein Networks by Colocalization Analysis (COLA)
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    Chapter 23 Development of Selected Reaction Monitoring Methods to Systematically Quantify Kinase Abundance and Phosphorylation Stoichiometry in Human Samples
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    Chapter 24 Analysis of Signaling Networks at the Single-Cell Level Using Mass Cytometry
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    Chapter 25 Magnetic Resonance Spectroscopy (MRS)-Based Methods for Examining Cancer Metabolism in Response to Oncogenic Kinase Drug Treatment
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    Chapter 26 Deconstructing the Metabolic Networks of Oncogenic Signaling Using Targeted Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
  28. Altmetric Badge
    Chapter 27 Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols
  29. Altmetric Badge
    Chapter 28 An Interdisciplinary Approach for Designing Kinetic Models of the Ras/MAPK Signaling Pathway
  30. Altmetric Badge
    Chapter 29 Databases and Computational Tools for Evolutionary Analysis of Protein Phosphorylation
  31. Altmetric Badge
    Chapter 30 Informatics Approaches for Predicting, Understanding, and Testing Cancer Drug Combinations
  32. Altmetric Badge
    Chapter 31 Target Inhibition Maps Based on Responses to Kinase Inhibitors
  33. Altmetric Badge
    Chapter 32 Partial Least Squares Regression Models for the Analysis of Kinase Signaling
Attention for Chapter 14: Cell-Specific Labeling for Analyzing Bidirectional Signaling by Mass Spectrometry
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

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Chapter title
Cell-Specific Labeling for Analyzing Bidirectional Signaling by Mass Spectrometry
Chapter number 14
Book title
Kinase Signaling Networks
Published in
Methods in molecular biology, July 2017
DOI 10.1007/978-1-4939-7154-1_14
Pubmed ID
Book ISBNs
978-1-4939-7152-7, 978-1-4939-7154-1
Authors

Christopher J. Tape, Claus Jørgensen

Abstract

Cell-specific proteome labeling enables global proteome-wide analysis of cell signaling in heterotypic co-cultures. Such approaches have provided unique insight in contact-initiated receptor tyrosine kinase signaling, transfer of proteomic material between heterotypic cells, and interactions between normal and oncogenic cells. Here we describe current methods for cell-specific labeling of heterotypic cells with isotopic labeled amino acids (e.g., SILAC and CTAP). We outline the advantages and disadvantages of individual approaches, describe typical experimental scenarios, and discuss where each experimental approach is optimally applied.

X Demographics

X Demographics

The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 33%
Researcher 2 17%
Unspecified 1 8%
Lecturer 1 8%
Unknown 4 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 42%
Unspecified 1 8%
Chemistry 1 8%
Medicine and Dentistry 1 8%
Unknown 4 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2017.
All research outputs
#4,748,235
of 22,990,068 outputs
Outputs from Methods in molecular biology
#1,384
of 13,150 outputs
Outputs of similar age
#82,886
of 314,579 outputs
Outputs of similar age from Methods in molecular biology
#14
of 270 outputs
Altmetric has tracked 22,990,068 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,150 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 314,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 270 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.