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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen
|
|---|---|
| Published in |
Nature Communications, April 2014
|
| DOI | 10.1038/ncomms4508 |
| Pubmed ID | |
| Authors |
Shariq M. Usmani, Onofrio Zirafi, Janis A. Müller, Nathallie L. Sandi-Monroy, Jay K. Yadav, Christoph Meier, Tanja Weil, Nadia R. Roan, Warner C. Greene, Paul Walther, K. Peter R. Nilsson, Per Hammarström, Ronald Wetzel, Christopher D. Pilcher, Friedrich Gagsteiger, Marcus Fändrich, Frank Kirchhoff, Jan Münch |
| Abstract |
Naturally occurring fragments of the abundant semen proteins prostatic acid phosphatase (PAP) and semenogelins form amyloid fibrils in vitro. These fibrils boost HIV infection and may play a key role in the spread of the AIDS pandemic. However, the presence of amyloid fibrils in semen remained to be demonstrated. Here, we use state of the art confocal and electron microscopy techniques for direct imaging of amyloid fibrils in human ejaculates. We detect amyloid aggregates in all semen samples and find that they partially consist of PAP fragments, interact with HIV particles and increase viral infectivity. Our results establish semen as a body fluid that naturally contains amyloid fibrils that are exploited by HIV to promote its sexual transmission. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 20% |
| United States | 1 | 20% |
| Australia | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Practitioners (doctors, other healthcare professionals) | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 116 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 22% |
| Researcher | 25 | 21% |
| Student > Master | 10 | 9% |
| Student > Bachelor | 9 | 8% |
| Professor | 7 | 6% |
| Other | 20 | 17% |
| Unknown | 20 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 24% |
| Agricultural and Biological Sciences | 26 | 22% |
| Chemistry | 11 | 9% |
| Immunology and Microbiology | 7 | 6% |
| Medicine and Dentistry | 7 | 6% |
| Other | 12 | 10% |
| Unknown | 26 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2020.
All research outputs
#534,799
of 22,751,628 outputs
Outputs from Nature Communications
#9,458
of 46,844 outputs
Outputs of similar age
#5,349
of 226,111 outputs
Outputs of similar age from Nature Communications
#77
of 476 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,844 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 226,111 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 476 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.