Title |
New Hypofractionation Radiation Strategies for Glioblastoma
|
---|---|
Published in |
Current Oncology Reports, July 2017
|
DOI | 10.1007/s11912-017-0616-3 |
Pubmed ID | |
Authors |
Melissa Azoulay, Jennifer Shah, Erqi Pollom, Scott G. Soltys |
Abstract |
Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults, with a median survival of less than 2 years despite the standard of care treatment of 6 weeks of chemoradiotherapy. We review the data investigating hypofractionated radiotherapy (HFRT) in the treatment of newly diagnosed GBM. Investigators have explored alternative radiotherapy strategies that shorten treatment duration with the goal of similar or improved survival while minimizing toxicity. HFRT over 1-3 weeks is already a standard of care for patients with advanced age or poor performance status. For young patients with good performance status, HFRT holds the promise of radiobiologically escalating the dose and potentially improving local control while maintaining quality of life. Through the use of shorter radiotherapy fractionation regimens coupled with novel systemic agents, improved outcomes for patients with GBM may be achieved. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 6 | 15% |
Student > Bachelor | 6 | 15% |
Student > Doctoral Student | 4 | 10% |
Student > Master | 3 | 7% |
Professor > Associate Professor | 2 | 5% |
Other | 6 | 15% |
Unknown | 14 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 19 | 46% |
Neuroscience | 2 | 5% |
Engineering | 2 | 5% |
Physics and Astronomy | 1 | 2% |
Materials Science | 1 | 2% |
Other | 1 | 2% |
Unknown | 15 | 37% |