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Of self‐lipids, CD1‐restricted T cells, and contact sensitization

Overview of attention for article published in European Journal of Immunology, July 2017
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Title
Of self‐lipids, CD1‐restricted T cells, and contact sensitization
Published in
European Journal of Immunology, July 2017
DOI 10.1002/eji.201747112
Pubmed ID
Authors

Giulia Casorati, Paolo Dellabona

Abstract

Contact hypersensitivity (CHS) in rodents and contact dermatitis in humans are long-known pathological conditions caused by MHC-restricted T-cell responses. These responses are triggered upon T-cell recognition of neo-antigenic determinants, which are generated by a variety of environmental contact sensitizer (CS) chemicals associating with self-proteins to comprise these neo-antigens. In this issue of the European Journal of Immunology, Betts et al. [Eur. J. Immunol. 2017. 47: 1171-1180] provide intriguing data implying that common small molecule CSs such as dinitrochlorobenzene can also recruit and activate autoreactive CD1-restricted T cells specific for cell-endogenous lipids, which are enriched in human skin. The effects of dinitrochlorobenzene on CD1 T-cell recruitment and function were dependent on newly synthesized CD1 molecules and the presence of endogenous lipids. These findings shed new light on unanticipated mechanisms that have potential clinical relevance on a common and highly distressing disease state.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 43%
Student > Ph. D. Student 1 14%
Professor 1 14%
Student > Master 1 14%
Professor > Associate Professor 1 14%
Other 0 0%
Readers by discipline Count As %
Immunology and Microbiology 5 71%
Agricultural and Biological Sciences 1 14%
Neuroscience 1 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 November 2017.
All research outputs
#16,711,078
of 24,578,676 outputs
Outputs from European Journal of Immunology
#5,842
of 6,814 outputs
Outputs of similar age
#202,441
of 316,877 outputs
Outputs of similar age from European Journal of Immunology
#23
of 46 outputs
Altmetric has tracked 24,578,676 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,814 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.2. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,877 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.