Title |
Long-Term Health Outcomes in Offspring Born to Women with Diabetes in Pregnancy
|
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Published in |
Current Diabetes Reports, March 2014
|
DOI | 10.1007/s11892-014-0489-x |
Pubmed ID | |
Authors |
Abigail Fraser, Debbie A. Lawlor |
Abstract |
In this review, we critically assess recent evidence from human studies regarding the potential implications of exposure to maternal diabetes in-utero for long-term adiposity, cardiometabolic outcomes, and cognitive ability of the offspring. Evidence supports a direct causal role for exposure to maternal diabetes in utero in determining offspring long-term greater adiposity and adverse cardiometabolic health. Although a majority of observational studies report associations of exposure to maternal pregnancy diabetes with lower cognitive ability, there is also evidence supporting an opposite 'protective' intrauterine effect of exposure to maternal pregnancy diabetes on offspring cognitive ability. Epigenetic modification has been suggested as a mediator on the pathways from maternal pregnancy diabetes to long-term offspring outcomes and several recent studies that are reviewed here lend some support to this notion, but research in this area is still too novel to be conclusive. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | <1% |
United States | 1 | <1% |
Canada | 1 | <1% |
Unknown | 231 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 37 | 16% |
Student > Ph. D. Student | 28 | 12% |
Researcher | 25 | 11% |
Student > Bachelor | 20 | 9% |
Student > Doctoral Student | 19 | 8% |
Other | 43 | 18% |
Unknown | 62 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 89 | 38% |
Biochemistry, Genetics and Molecular Biology | 24 | 10% |
Nursing and Health Professions | 12 | 5% |
Agricultural and Biological Sciences | 8 | 3% |
Neuroscience | 5 | 2% |
Other | 27 | 12% |
Unknown | 69 | 29% |