| Chapter title |
Chemoprevention of prostate cancer with the polyamine synthesis inhibitor difluoromethylornithine.
|
|---|---|
| Chapter number | 14 |
| Book title |
Prostate Cancer Prevention
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, February 2014
|
| DOI | 10.1007/978-3-642-45195-9_14 |
| Pubmed ID | |
| Book ISBNs |
978-3-64-245194-2, 978-3-64-245195-9
|
| Authors |
Meyskens FL Jr, Simoneau AR, Gerner EW, Frank L. Meyskens, Anne R. Simoneau, Eugene W. Gerner, Meyskens, Frank L., Simoneau, Anne R., Gerner, Eugene W. |
| Abstract |
In vitro and in vivo preclinical results suggest that inhibition of polyamine synthesis inhibits the progression of prostate cancer. These findings has led to two clinical trials in patients at risk for invasive prostate cancer with difluoromethylornithine which specifically and irreversibly inhibits ornithine decarboxylase which catalyses the conversion of ornithine to putrescine the rate limiting step in polyamines synthesis. We have conducted a phase IIa one month and placebo randomized phase IIb 12 months trials in patients at increased risk for invasive prostate cancer. Favorable reduction in prostate polyamine levels and prostate volume was documented with no difference in clinical hearing changes. Patients with Gleason's VI lesions in a surveillance cohort would be appropriate candidates for a definitive risk reduction trial although the unavailability of validated biomarkers for invasive progression would require a large and lengthy study. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 4 | 19% |
| Student > Bachelor | 3 | 14% |
| Lecturer | 2 | 10% |
| Other | 2 | 10% |
| Researcher | 2 | 10% |
| Other | 4 | 19% |
| Unknown | 4 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 33% |
| Biochemistry, Genetics and Molecular Biology | 3 | 14% |
| Computer Science | 2 | 10% |
| Agricultural and Biological Sciences | 1 | 5% |
| Immunology and Microbiology | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 6 | 29% |