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The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments

Overview of attention for article published in Trials, March 2011
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Title
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments
Published in
Trials, March 2011
DOI 10.1186/1745-6215-12-62
Pubmed ID
Authors

Peter Connick, Madhan Kolappan, Rickie Patani, Michael A Scott, Charles Crawley, Xiao-Ling He, Karen Richardson, Kelly Barber, Daniel J Webber, Claudia AM Wheeler-Kingshott, Daniel J Tozer, Rebecca S Samson, David L Thomas, Ming-Qing Du, Shi L Luan, Andrew W Michell, Daniel R Altmann, Alan J Thompson, David H Miller, Alastair Compston, Siddharthan Chandran

Abstract

No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS). The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) trial tests the safety and feasibility of treatment with a candidate cell-based therapy, and will inform the wider challenge of designing early phase clinical trials to evaluate putative neuroprotective therapies in progressive MS. Illustrated by the MSCIMS trial protocol, we describe a novel methodology based on detailed assessment of the anterior visual pathway as a model of wider disease processes--the "sentinel lesion approach".

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Mendeley readers

The data shown below were compiled from readership statistics for 207 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
Turkey 1 <1%
India 1 <1%
Germany 1 <1%
Unknown 202 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 63 30%
Student > Ph. D. Student 26 13%
Researcher 25 12%
Student > Bachelor 18 9%
Other 12 6%
Other 31 15%
Unknown 32 15%
Readers by discipline Count As %
Medicine and Dentistry 55 27%
Agricultural and Biological Sciences 26 13%
Nursing and Health Professions 25 12%
Biochemistry, Genetics and Molecular Biology 13 6%
Neuroscience 13 6%
Other 36 17%
Unknown 39 19%