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Effects of novel hydroxyapatite‐based 3D biomaterials on proliferation and osteoblastic differentiation of mesenchymal stem cells

Overview of attention for article published in Journal of Biomedical Materials Research, Part A, April 2014
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Title
Effects of novel hydroxyapatite‐based 3D biomaterials on proliferation and osteoblastic differentiation of mesenchymal stem cells
Published in
Journal of Biomedical Materials Research, Part A, April 2014
DOI 10.1002/jbm.a.35180
Pubmed ID
Authors

Ivana Karadzic, Vesna Vucic, Vukoman Jokanovic, Jasmina Debeljak‐Martacic, Dejan Markovic, Snjezana Petrovic, Marija Glibetic

Abstract

The aim of this study was to examine the differential capacity of isolated dental pulp stem cells (SHED) cultured onto four different scaffold materials. The differential potential of isolated SHED was examined on the following scaffolds: porous hydroxyapatite (pHAP) alone or combined with three polymers [polylactic-co-glycolic acid (PLGA), alginate, and ethylene vinylacetate / ethylene vinylversatate (EVA/EVV)]. SHED were isolated by "outgrowth" method and characterized by the flow cytometry. Viability of cells grown with scaffolds was assessed by MTT and LDH assays. No significant cytotoxic effect of any of the tested materials was shown. Staining with alizarin red and estimated alkaline phosphatase activity to identify differentiation, demonstrated osteoblastic phenotype of SHED and newly deposited and mineralized extra cellular matrix (ECM) in presence of all tested scaffolds. The developed ECM seen at scanning electronic micrographs additionally confirmed the osteogenic differentiation and biocompatibility between cells and materials. In summary, all studied biomaterials are suitable carriers for proliferation and osteoblastic differentiation of dental pulp mesenchymal stem cells in vitro. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2014.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 2 3%
Serbia 2 3%
India 1 1%
Unknown 66 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 24%
Student > Ph. D. Student 14 20%
Student > Master 8 11%
Student > Bachelor 7 10%
Student > Doctoral Student 4 6%
Other 13 18%
Unknown 8 11%
Readers by discipline Count As %
Medicine and Dentistry 20 28%
Agricultural and Biological Sciences 12 17%
Engineering 9 13%
Biochemistry, Genetics and Molecular Biology 7 10%
Materials Science 4 6%
Other 10 14%
Unknown 9 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2014.
All research outputs
#22,759,452
of 25,374,647 outputs
Outputs from Journal of Biomedical Materials Research, Part A
#2,421
of 2,627 outputs
Outputs of similar age
#207,516
of 238,628 outputs
Outputs of similar age from Journal of Biomedical Materials Research, Part A
#18
of 27 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,627 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 238,628 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.