Title |
Alt a 1 from Alternaria interacts with PR5 thaumatin‐like proteins
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Published in |
Febs Letters, March 2014
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DOI | 10.1016/j.febslet.2014.02.044 |
Pubmed ID | |
Authors |
Cristina Gómez-Casado, Amaya Murua-García, María Garrido-Arandia, Pablo González-Melendi, Rosa Sánchez-Monge, Domingo Barber, Luis F. Pacios, Araceli Díaz-Perales |
Abstract |
Alt a 1 is a protein found in Alternaria alternata spores related to virulence and pathogenicity and considered to be responsible for chronic asthma in children. We found that spores of Alternaria inoculated on the outer surface of kiwifruits did not develop hyphae. Nevertheless, the expression of Alt a 1 gene was upregulated, and the protein was detected in the pulp where it co-localized with kiwi PR5. Pull-down assays demonstrated experimentally that the two proteins interact in such a way that Alt a 1 inhibits the enzymatic activity of PR5. These results are relevant not only for plant defense, but also for human health as patients with chronic asthma could suffer from an allergic reaction when they eat fruit contaminated with Alternaria. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 1 | 2% |
Italy | 1 | 2% |
Canada | 1 | 2% |
Unknown | 50 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 19% |
Student > Doctoral Student | 5 | 9% |
Researcher | 4 | 8% |
Professor > Associate Professor | 4 | 8% |
Student > Master | 4 | 8% |
Other | 11 | 21% |
Unknown | 15 | 28% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 16 | 30% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Medicine and Dentistry | 5 | 9% |
Immunology and Microbiology | 3 | 6% |
Business, Management and Accounting | 1 | 2% |
Other | 4 | 8% |
Unknown | 18 | 34% |