| Title |
Three-dimensional assessment of left atrial appendage orifice geometry and potential implications for device closure
|
|---|---|
| Published in |
The International Journal of Cardiovascular Imaging, March 2014
|
| DOI | 10.1007/s10554-014-0393-0 |
| Pubmed ID | |
| Authors |
Julie O’Brien, Donya Al-hassan, Justin Ng, Madalsa Joshi, Cameron Hague, Santabhanu Chakrabarti, Jonathon Leipsic |
| Abstract |
Transcatheter placement of left atrial closure device is an attractive therapy for patients with atrial fibrillation (AF), to avoid anticoagulation and reduce cerebrovascular events; however peri-device leaks occur. The geometry of the left atrial appendage (LAA) is not well understood, largely owing to limitations of 2-dimensional imaging techniques. We sought to better define the LAA orifice geometry, by performing 3-dimensional multi-detector computed tomography measurements. We prospectively recruited 105 consecutive patients referred for pulmonary vein ablation (PVA) and age-matched controls. Area, short and long-axis measurements were performed. Eccentricity was calculated as 1-(short axis/long axis). Multiple clinical variables were tested for their ability to predict appendage orifice eccentricity using univariate linear regression models. The PVA cohort demographics included; 25 (24%) females, mean age 59 years (SD = 10), median height (1.55-2.03), weight 89 (56-139) kg and body surface area 2.1 (1.61-2.58). In the PVA cohort, there was a significant difference between the long and short-axis; median short-axis dimension was 20.5 (12.9-35.4) mm, versus long-axis median 30.4 (17.7-43.8) (p < 0.001). Mean eccentricity score was 0.4. When compared with controls, there was a significant difference in the short and long-axis measurements (p < 0.001) as well as eccentricity (p = 0.04). All clinical variables tested showed limited ability to predict appendage eccentricity (p = NS). LAA ostium is an elliptical structure in the setting of AF with a high eccentricity index and uniformly significant differences between short and long-axis. There were significant differences between these parameters when compared with controls. A deeper appreciation of LAA geometry and eccentricity may allow for reduction in peri-closure leaks. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Saudi Arabia | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Slovenia | 1 | 5% |
| Unknown | 20 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 24% |
| Student > Doctoral Student | 3 | 14% |
| Student > Bachelor | 3 | 14% |
| Student > Ph. D. Student | 2 | 10% |
| Librarian | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 5 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 57% |
| Nursing and Health Professions | 1 | 5% |
| Materials Science | 1 | 5% |
| Agricultural and Biological Sciences | 1 | 5% |
| Unknown | 6 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2014.
All research outputs
#19,945,185
of 25,374,917 outputs
Outputs from The International Journal of Cardiovascular Imaging
#1,116
of 2,012 outputs
Outputs of similar age
#165,765
of 235,892 outputs
Outputs of similar age from The International Journal of Cardiovascular Imaging
#13
of 45 outputs
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