Title |
Gene–ethanol interactions underlying fetal alcohol spectrum disorders
|
---|---|
Published in |
Cellular and Molecular Life Sciences, February 2014
|
DOI | 10.1007/s00018-014-1578-3 |
Pubmed ID | |
Authors |
Neil McCarthy, Johann K. Eberhart |
Abstract |
Fetal alcohol spectrum disorders (FASD) is an umbrella term that describes a diverse set of ethanol-induced defects. The phenotypic variation is generated by numerous factors, including timing and dosage of ethanol exposure as well as genetic background. We are beginning to learn about how the concentration, duration, and timing of ethanol exposure mediate variability within ethanol teratogenesis. However, little is known about the genetic susceptibilities in FASD. Studies of FASD animal models are beginning to implicate a number of susceptibility genes that are involved in various pathways. Here we review the current literature that focuses on the genetic predispositions in FASD. |
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Geographical breakdown
Country | Count | As % |
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United States | 2 | 50% |
Canada | 1 | 25% |
United Kingdom | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 54 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 10 | 19% |
Student > Master | 8 | 15% |
Student > Doctoral Student | 7 | 13% |
Student > Bachelor | 7 | 13% |
Researcher | 6 | 11% |
Other | 11 | 20% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 15% |
Biochemistry, Genetics and Molecular Biology | 6 | 11% |
Unspecified | 3 | 6% |
Neuroscience | 3 | 6% |
Other | 5 | 9% |
Unknown | 9 | 17% |