| Title |
Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, February 2014
|
| DOI | 10.1007/s00424-014-1463-9 |
| Pubmed ID | |
| Authors |
Yonggang Ma, Lisandra E. de Castro Brás, Hiroe Toba, Rugmani Padmanabhan Iyer, Michael E. Hall, Michael D. Winniford, Richard A. Lange, Suresh C. Tyagi, Merry L. Lindsey |
| Abstract |
The cardiac extracellular matrix (ECM) fills the space between cells, supports tissue organization, and transduces mechanical, chemical, and biological signals to regulate homeostasis of the left ventricle (LV). Following myocardial infarction (MI), a multitude of ECM proteins are synthesized to replace myocyte loss and form a reparative scar. Activated fibroblasts (myofibroblasts) are the primary source of ECM proteins, thus playing a key role in cardiac repair. A balanced turnover of ECM through regulation of synthesis by myofibroblasts and degradation by matrix metalloproteinases (MMPs) is critical for proper scar formation. In this review, we summarize the current literature on the roles of myofibroblasts, MMPs, and ECM proteins in MI-induced LV remodeling. In addition, we discuss future research directions that are needed to further elucidate the molecular mechanisms of ECM actions to optimize cardiac repair. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 177 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| China | 1 | <1% |
| Unknown | 173 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 49 | 28% |
| Student > Master | 22 | 12% |
| Student > Bachelor | 22 | 12% |
| Researcher | 19 | 11% |
| Student > Doctoral Student | 10 | 6% |
| Other | 18 | 10% |
| Unknown | 37 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 36 | 20% |
| Medicine and Dentistry | 30 | 17% |
| Agricultural and Biological Sciences | 27 | 15% |
| Engineering | 15 | 8% |
| Nursing and Health Professions | 3 | 2% |
| Other | 20 | 11% |
| Unknown | 46 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2014.
All research outputs
#21,162,249
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#1,798
of 1,973 outputs
Outputs of similar age
#276,077
of 317,813 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#26
of 28 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 317,813 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.