| Title |
Beyond a Broken Heart: Circulatory Dysfunction in the Failing Fontan
|
|---|---|
| Published in |
Pediatric Cardiology, February 2014
|
| DOI | 10.1007/s00246-014-0881-y |
| Pubmed ID | |
| Authors |
Makoto Mori, Alfredo J. Aguirre, Robert W. Elder, Ali Kashkouli, Alton Brad Farris, Ryan M. Ford, Wendy M. Book |
| Abstract |
The role of ventricular dysfunction in late morbidity and mortality of univentricular hearts has been described previously. However, a significant proportion of adult Fontan patients who die or require heart transplantation do so with preserved ventricular function. The clinical deterioration in patients who have undergone Fontan palliation requires a broader view of circulatory dysfunction, one that takes into account the complex interaction of regulatory systems affecting hepatic, renal, and pulmonary blood flow, in addition to cardiac function. This review focuses primarily on the pathophysiology of multiple organ involvement in this circulatory dysfunction, with particular focus on the consequences of hepatic dysfunction and portal hypertension. The authors discuss hepatic perfusion, both in health and disease, and review the current understanding of liver histopathology and liver disease in adult Fontan patients and similar clinicopathologic states. They compare and contrast features of postsinusoidal portal hypertension with more typical adult cirrhotic disease. Finally, they delineate the related effects of portal hypertensive physiology on the systemic and pulmonary vasculature, the kidney, and the heart itself and discuss how these changes affect the care of the adult Fontan patient. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 60% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Practitioners (doctors, other healthcare professionals) | 1 | 20% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 118 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 116 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 14% |
| Researcher | 16 | 14% |
| Other | 15 | 13% |
| Student > Bachelor | 12 | 10% |
| Student > Doctoral Student | 11 | 9% |
| Other | 32 | 27% |
| Unknown | 15 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 68 | 58% |
| Engineering | 11 | 9% |
| Nursing and Health Professions | 7 | 6% |
| Agricultural and Biological Sciences | 6 | 5% |
| Mathematics | 2 | 2% |
| Other | 3 | 3% |
| Unknown | 21 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2022.
All research outputs
#7,741,906
of 23,543,207 outputs
Outputs from Pediatric Cardiology
#289
of 1,439 outputs
Outputs of similar age
#104,628
of 340,438 outputs
Outputs of similar age from Pediatric Cardiology
#8
of 41 outputs
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So far Altmetric has tracked 1,439 research outputs from this source. They receive a mean Attention Score of 2.9. This one has gotten more attention than average, scoring higher than 66% of its peers.
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