| Title |
Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat
|
|---|---|
| Published in |
Obesity Surgery, February 2013
|
| DOI | 10.1007/s11695-013-0884-4 |
| Pubmed ID | |
| Authors |
Jon F. Davis, Andrea L. Tracy, Jennifer D. Schurdak, Irwin J. Magrisso, Bernadette E. Grayson, Randy J. Seeley, Stephen C. Benoit |
| Abstract |
Roux en Y gastric bypass (RYGB) surgery is currently the most effective therapy employed to treat obesity and its associated complications. In addition to weight loss and resolution of metabolic syndromes, such as diabetes, the RYGB procedure has been reported to increase alcohol consumption in humans. Using an outbred rodent model, we demonstrate that RYGB increases postsurgical ethanol consumption, that this effect cannot be explained solely by postsurgical weight loss and that it is independent of presurgical body weight or dietary composition. Altered ethanol metabolism and postsurgical shifts in release of ghrelin were also unable to account for changes in alcohol intake. Further investigation of the potential physiological factors underlying this behavioral effect identified altered patterns of gene expression in brain regions associated with reward following RYGB surgery. These findings have important clinical implications as they demonstrate that RYGB surgery leads directly to increased alcohol intake in otherwise alcohol nonpreferring rat and induces neurobiological changes in brain circuits that mediate a variety of appetitive behaviors. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Brazil | 1 | 2% |
| Unknown | 49 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 14% |
| Professor > Associate Professor | 6 | 12% |
| Student > Doctoral Student | 6 | 12% |
| Student > Bachelor | 5 | 10% |
| Researcher | 4 | 8% |
| Other | 9 | 18% |
| Unknown | 14 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 22% |
| Psychology | 7 | 14% |
| Agricultural and Biological Sciences | 5 | 10% |
| Neuroscience | 4 | 8% |
| Nursing and Health Professions | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 18 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 January 2015.
All research outputs
#4,565,054
of 22,751,628 outputs
Outputs from Obesity Surgery
#623
of 3,366 outputs
Outputs of similar age
#38,580
of 193,003 outputs
Outputs of similar age from Obesity Surgery
#7
of 33 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,366 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 193,003 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.