| Title |
Modulation of Myelin Basic Protein Gene Expression by Acetyl-l-Carnitine
|
|---|---|
| Published in |
Molecular Neurobiology, May 2011
|
| DOI | 10.1007/s12035-011-8189-x |
| Pubmed ID | |
| Authors |
Giovanna Traina, Giuseppe Federighi, Monica Macchi, Rodolfo Bernardi, Mauro Durante, Marcello Brunelli |
| Abstract |
Acetyl-L-carnitine (ALC), the acetyl ester of L-carnitine, is a naturally occurring molecule which plays an essential role in intermediary and mitochondrial metabolism. It has also neurotrophic and antioxidant actions, demonstrating efficacy and high tolerability in the treatment of neuropathies of various etiologies. ALC is a molecule of considerable interest for its clinical application in various neural disorders, although little is known regarding its effects on gene expression. Suppression subtractive hybridization methodology was used for the generation of subtracted complementary DNA libraries and the subsequent identification of differentially expressed transcripts in the rat brain after chronic ALC treatments. We provided evidence for a downregulation of the expression of all of the isoforms of myelin basic protein gene following prolonged ALC treatment, indicating a possible role in the modulation of myelin basic protein turnover, stabilizing and maintaining myelin integrity. |
Mendeley readers
The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 2 | 14% |
| Student > Bachelor | 2 | 14% |
| Student > Ph. D. Student | 2 | 14% |
| Lecturer | 1 | 7% |
| Other | 1 | 7% |
| Other | 4 | 29% |
| Unknown | 2 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 21% |
| Medicine and Dentistry | 3 | 21% |
| Neuroscience | 2 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Nursing and Health Professions | 1 | 7% |
| Other | 0 | 0% |
| Unknown | 4 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2022.
All research outputs
#8,882,501
of 26,017,215 outputs
Outputs from Molecular Neurobiology
#1,689
of 4,044 outputs
Outputs of similar age
#48,205
of 128,235 outputs
Outputs of similar age from Molecular Neurobiology
#4
of 11 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,044 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one has gotten more attention than average, scoring higher than 51% of its peers.
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