| Title |
Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome
|
|---|---|
| Published in |
Heart Failure Reviews, January 2011
|
| DOI | 10.1007/s10741-010-9225-z |
| Pubmed ID | |
| Authors |
Suzan Willemsen, Jasper W. L. Hartog, M. Rebecca Heiner-Fokkema, Dirk J. van Veldhuisen, Adriaan A. Voors |
| Abstract |
The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients with diabetes mellitus and in patients with renal failure. Through the formation of collagen crosslinks, and by interaction with the AGE-receptor, which impairs calcium handling and increases fibrosis, AGE-accumulation has pathophysiologically been associated with the development of diastolic and renal dysfunction. Interestingly, diastolic dysfunction is a frequent finding in elderly patients, diabetic patients and in patients with renal failure. Taken together, this suggests that AGEs are related to the development and progression of diastolic HF and renal failure. In this review, the role of AGEs as a possible pathophysiological factor that link the development and progression of heart and renal failure, is discussed. Finally, the role of AGE intervention as a possible treatment in HF patients will be discussed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 2 | 2% |
| Mexico | 1 | 1% |
| Russia | 1 | 1% |
| Unknown | 87 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 15% |
| Researcher | 10 | 11% |
| Other | 5 | 5% |
| Student > Postgraduate | 5 | 5% |
| Student > Bachelor | 4 | 4% |
| Other | 13 | 14% |
| Unknown | 40 | 44% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 25% |
| Agricultural and Biological Sciences | 13 | 14% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Psychology | 3 | 3% |
| Sports and Recreations | 2 | 2% |
| Other | 6 | 7% |
| Unknown | 40 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2014.
All research outputs
#18,369,403
of 22,751,628 outputs
Outputs from Heart Failure Reviews
#547
of 666 outputs
Outputs of similar age
#161,694
of 182,456 outputs
Outputs of similar age from Heart Failure Reviews
#3
of 3 outputs
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