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A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect

Overview of attention for article published in Nature Communications, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (62nd percentile)

Mentioned by

news
1 news outlet
twitter
10 X users
peer_reviews
1 peer review site
facebook
1 Facebook page
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
94 Dimensions

Readers on

mendeley
127 Mendeley
citeulike
2 CiteULike
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Title
A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect
Published in
Nature Communications, April 2014
DOI 10.1038/ncomms4608
Pubmed ID
Authors

Paula Lopez-Serra, Miguel Marcilla, Alberto Villanueva, Antonio Ramos-Fernandez, Anna Palau, Lucía Leal, Jessica E. Wahi, Fernando Setien-Baranda, Karolina Szczesna, Catia Moutinho, Anna Martinez-Cardus, Holger Heyn, Juan Sandoval, Sara Puertas, August Vidal, Xavier Sanjuan, Eva Martinez-Balibrea, Francesc Viñals, Jose C. Perales, Jesper B. Bramsem, Torben F. Ørntoft, Claus L. Andersen, Josep Tabernero, Ultan McDermott, Matthew B. Boxer, Matthew G. Vander Heiden, Juan Pablo Albar, Manel Esteller

Abstract

Cancer cells possess aberrant proteomes that can arise by the disruption of genes involved in physiological protein degradation. Here we demonstrate the presence of promoter CpG island hypermethylation-linked inactivation of DERL3 (Derlin-3), a key gene in the endoplasmic reticulum-associated protein degradation pathway, in human tumours. The restoration of in vitro and in vivo DERL3 activity highlights the tumour suppressor features of the gene. Using the stable isotopic labelling of amino acids in cell culture workflow for differential proteome analysis, we identify SLC2A1 (glucose transporter 1, GLUT1) as a downstream target of DERL3. Most importantly, SLC2A1 overexpression mediated by DERL3 epigenetic loss contributes to the Warburg effect in the studied cells and pinpoints a subset of human tumours with greater vulnerability to drugs targeting glycolysis.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 <1%
Argentina 1 <1%
Denmark 1 <1%
Spain 1 <1%
Japan 1 <1%
United States 1 <1%
Unknown 121 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 27 21%
Student > Ph. D. Student 19 15%
Student > Bachelor 17 13%
Student > Doctoral Student 14 11%
Student > Master 8 6%
Other 21 17%
Unknown 21 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 31%
Agricultural and Biological Sciences 27 21%
Medicine and Dentistry 14 11%
Chemistry 6 5%
Engineering 4 3%
Other 11 9%
Unknown 26 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2017.
All research outputs
#1,603,569
of 22,751,628 outputs
Outputs from Nature Communications
#21,180
of 46,844 outputs
Outputs of similar age
#17,349
of 225,522 outputs
Outputs of similar age from Nature Communications
#178
of 476 outputs
Altmetric has tracked 22,751,628 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,844 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.6. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 225,522 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 476 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 62% of its contemporaries.